Introduction of GJA5
The gap junction alpha-5 protein (GJA5) is a protein which is encoded by the GJA5 gene. It is also known as connexin-40 (Cx40). This gene is a member of the connexin gene family. The encoded protein is a component of the gap junction and consists of a series of intercellular channels that provide a pathway for the diffusion of low molecular weight species from cells to cells. Mutations in this gene may be involved in atrial fibrillation. A gap junction consists of a dense set of transmembrane channels, the linkers, through which low MW species diffuse from one cell to adjacent cells.
|Basic Information of GJA5|
|Protein Name||Gap junction alpha-5 protein|
|Organism||Homo sapiens (Human)|
Function of GJA5 Membrane Protein
GJA5 has been identified as a gene for observing the phenotype of congenital heart disease at 1q21.1. If there is repeated GJA5 quadruple disease, it is more common. Other congenital heart diseases are more common if there are other congenital heart diseases. The Cx family consists of 20 members, named according to their molecular weight. GJA5 is expressed in PASMCs. Previous studies have shown that GJA5 is involved in the development of edema and inflammation during certain lung injuries. However, it is unclear whether GJA5 will affect the progression of hyperoxia-induced acute lung injury.
Fig.1 Genetic Variants Identified by Genome-wide Association Studies. (Mahida, 2014)
Application of GJA5 Membrane Protein in Literature
This study adds to evidence supporting the importance of GJA5 alterations (especially reductions relative to Cx43) in AF.
It is pointed out herein that Cx37 is more important than GJA5 in relation to the release of essential NO, the release of cyclooxygenase products, and the regulation of ACh sensitivity.
The results indicate that loss of endothelial GJA5 can reduce tumor growth and blood vessels, independent of hypertension.
The authors found in vitro that sildenafil increased GJA5 expression in PASMCs isolated from MCT-PAH rats and inhibited proliferation of these cells.
This study showed that exposure to hypoxemia impaired the tight junction structure between vascular endothelial cells and decreased GJA5.
GJA5 Preparation Options
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