GLP2R Membrane Protein Introduction

Introduction of GLP2R

The glucagon-like peptide 2 receptor (GLP2R) is a receptor protein encoded by the gene GLP2R. The G protein activates adenylate cyclase to mediate the activity of the GLP2R receptor. GLP2 signaling can stimulate intestinal growth and increase the villus height in the small intestine, accompanied by an increase in crypt cell proliferation and a decrease in intestinal cell apoptosis.

Basic Information of GLP2R
Protein Name Glucagon-like peptide 2 receptor
Gene Name GLP2R
Aliases GLP-2-R
Organism Homo sapiens (Human)
UniProt ID O95838
Transmembrane Times 7
Length (aa) 553

Function of GLP2R Membrane Protein

GLP2R is a receptor for glucagon-like peptide 2. Glucagon-like peptide-2 (GLP-2) is a 33 amino acid glucagon-derived peptide produced by enteroendocrine cells that can act as a growth factor to enlarge the surface area of mucosal epithelium. GLP2 binds to GLP2R to stimulate intestinal growth and up-regulate the villus height in the small intestine, accompanied by an increase in crypt cell proliferation and a decrease in intestinal cell apoptosis. In addition, GLP2 prevents intestinal hypoplasia caused by total parenteral nutrition.

Structure of GLP2R. Fig.1 Structure of GLP2R.

Application of GLP2R Membrane Protein in Literature

  1. Lee S.J., et al. Disruption of the Murine Glp2r Impairs Paneth Cell Function and Increases Susceptibility to Small Bowel Enteritis. Endocrinology. 2012, 153(3): 1141–1151. PubMed ID: 22253424

    This research reports an important role in preventing intestinal mucosal damage and maintaining basal GLP-2R activity in normal host-bacterial interactions in the gastrointestinal tract.

  2. Guan X., et al. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012, 303(7): E853–E864. PubMed ID: 22829581

    This paper reveals that the central nervous system (CNS) GLP-2R plays an important physiological role in controlling food intake and gastric emptying. The melanocortin system mediates POMC neurons regulating CNS food intake and gastric emptying.

  3. Lee J., et al. Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport. Mol Metab. 2017, 6(3): 245–255. PubMed ID: 28271031

    This article reveals that GLP-2R signaling plays an important role in the physiological and pharmacological control of amino acid perception and assimilation in the intestine.

  4. Koehler J.A., et al. Glucagon-like Peptide-2 Does Not Modify the Growth or Survival of Murine or Human Intestinal Tumor Cells. Cancer Res. 2008, 68(19): 7897–7904.PubMed ID: 18829546

    This article suggests that GLP-2R activation contributes to the signaling pathways that promote normal intestinal epithelial cell proliferation and cytoprotection, but that sustained regulation of GLP-2R signaling does not alter the growth or survival of intestinal tumor cells.

  5. Shi X., et al. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013, 18(1): 86–98. PubMed ID: 23823479

    Glucose intolerance and hepatic insulin resistance in mouse POMC neurons of the GLP-2 receptor (GLP-2R) are evaluated in this paper. GLP-2R activation is required for GLP-2 to enhance insulin-mediated inhibition of hepatic glucose production (HGP) and gluconeogenesis.

GLP2R Preparation Options

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