Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | G protein-coupled receptor class C group 5 member D |
| Gene Name | GPRC5D |
| Uniprot | Q9NZD1 (Human); Q9JIL6 (Mouse) |
| Synonym | G-protein coupled receptor family C group 5 member D; orphan G-protein coupled receptor |
| Background | GPRC5D is one of the orphan G-protein coupled receptors (GPCRs), with homology to members of family C GPCRs. A characteristic feature of the family C GPCRs is their unusually large extracellular amino-terminal domain (ATD) of about 500~600 amino acids, which is considerably longer than those seen in family A and B receptors. However, the GPRC5D receptor, together with RAIG1, GPRC5B, and GPRC5C, form a new group within family C based on their homology with members of this receptor family and the lack of homology to family A and B GPCRs. These receptors have short ATDs of about 30~50 amino acids. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX485 | NativeExtract™ Human GPRC5D Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0423-KX9 | MemDX™ Human GPRC5D Membrane Protein in Endosome (EXO), Full Length | HEK293 cells | Full length | EXO |
| MPVLP-048 | MemDX™ Recombinant Human GPRC5D Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX0893K | MemDX™ Membrane Protein Human GPRC5D Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0483X | MemDX™ Membrane Protein Human GPRC5D (G protein-coupled receptor class C group 5 member D) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
With our advanced cell line construction platform and extensive experience, we offer you high-quality and highly stable membrane protein stable cell lines to support your research and drug development.
| CAT# | Product Name | Target Species | Host Cell |
| S01YF-0324-KX33 | MemDX™ Human GPRC5D A20 Cell Line | Human | A20 |
| S01YF-0123-KX32 | MemDX™ Human GPRC5D HEK293T Cell Line | Human | HEK293T |
| Please contact us for more products or customization | |||
Vi***nne: Creative Biolabs' GPRC5D exhibits superior purity and functionality in binding assays.
23/Aug/2023
J***an: Efficient customization (multiple tags, species variants) and rapid turnaround.
06/Jun/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers GPRC5D knockout services. The advent of genome editing offers unprecedented precision for inactivating oncogenic or disease-associated targets like GPRC5D. For example, RNAs designed to target conserved exonic regions of GPRC5D can induce frameshift mutations, effectively ablating its expression in preclinical models of multiple myeloma. This approach is particularly relevant for malignancies where GPRC5D overexpression drives tumor survival. Creative Biolabs' proprietary RNA validation platforms ensure high specificity, minimizing off-target effects while maximizing therapeutic potential.
Creative Biolabs offers AAV-delivered shRNA for sustained GPRC5D suppression services. Adeno-associated virus (AAV) vectors engineered to deliver short hairpin RNA (shRNA) against GPRC5D enable tissue-specific, durable suppression of target expression. Preclinical studies demonstrate that intra-tumoral injection of AAV-shRNA constructs reduces GPRC5D protein levels by >80% in syngeneic tumor models, synergizing with checkpoint inhibitors to enhance antitumor immunity. Creative Biolabs' expertise in vector optimization ensures high transduction efficiency and minimal immunogenicity, a critical advantage for clinical translation.
Creative Biolabs offers comprehensive and innovative services to drive the development of GPRC5D cell therapy. Please for more services.
Creative Biolabs offers CAR-T cell engineering services. CAR-T cells engineered with high-affinity scFvs against GPRC5D extracellular domains exhibit potent cytotoxicity in GPRC5D-positive malignancies. For instance, second-generation CARs incorporating 4-1BB co-stimulatory domains have demonstrated >90% target cell elimination in vitro, with robust persistence in xenograft models. Creative Biolabs' end-to-end CAR development services, from scFv screening to functional validation, accelerate the path from discovery to IND-enabling studies.
Creative Biolabs offers TCR-like antibody-guided T-cell recruitment services. Bispecific antibodies targeting GPRC5D and CD3ε can redirect endogenous T cells to eliminate GPRC5D-expressing tumors. Preclinical data reveal that these molecules induce T-cell-mediated lysis at picomolar concentrations, even in low-antigen-density environments. Creative Biolabs' advanced protein engineering platforms enable rapid generation of humanized, affinity-optimized constructs, ensuring clinical viability and reduced immunogenicity risks.
Creative Biolabs offers NK cell engineering services. Natural killer (NK) cells armed with GPRC5D-targeting CARs offer a promising alternative to T-cell therapies, particularly for allogeneic applications. In vitro co-culture assays show that CAR-NK cells secrete granzyme B and IFN-γ upon target engagement, achieving >70% tumor cell killing within 24 hours. Leverage Creative Biolabs' expertise in NK cell expansion and cryopreservation to streamline scalable manufacturing workflows.
GPRC5D represents a high-value target with transformative potential across gene and cell therapy modalities. Creative Biolabs' vertically integrated platform—spanning target validation, vector design, and functional analytics—empowers clients to de-risk development and accelerate timelines. to schedule a comprehensive consultation and explore how our bespoke solutions can catalyze your GPRC5D-focused pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
