Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | 5-hydroxytryptamine receptor 1B |
| Gene Name | HTR1B |
| Uniprot | P28222 (Human); P28334 (Mouse) |
| Synonym | S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; serotonin 1D beta receptor; serotonin receptor 1B |
| Background | 5-hydroxytryptamine receptor 1B, also known as 5-HT-1B or 5-HT1B, is encoded by HTR1B gene in human. It is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT), and belongs to the G protein-coupled receptor (GPCR) family. HTR1B is widely expressed throughout the CNS central nervous system with the highest concentrations found in the frontal cortex, basal ganglia, striatum, and the hippocampus. The function of the HTR1B differs relying on its location. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX351 | NativeExtract™ Human HTR1B Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX166 | MemDX™ Recombinant Human HTR1B Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| Please for more products or customization | ||||
L**a: I recently purchased proteins from Creative Biolabs, and I must say, their team was incredibly responsible and professional. They provided detailed information about the product and were very responsive to my inquiries.
22/ May/2023
D***a: They provided great guidance and support, and the product exceeded my expectations. I highly recommend them for anyone in need of high-quality protein products. They truly go above and beyond!
13/ Oct/2024
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Creative Biolabs offers targeted gene editing services. The advent of advanced gene editing platforms, prominently featuring sophisticated methodologies, now permits the execution of highly precise sequence modifications directly within the HTR1B gene locus. Such targeted genomic intervention capabilities are regarded with substantial optimism, as they may provide a viable pathway for rectifying specific genetic aberrations in HTR1B. These aberrations are frequently implicated in the pathophysiology of a range of debilitating neuropsychiatric disorders, which could encompass conditions like major depressive disorder, various anxiety spectrum disorders, and substance use disorders.
Creative Biolabs offers RNA interference services. Selective post-transcriptional silencing of HTR1B messenger RNA (mRNA) expression represents a potent molecular strategy, achievable through the judicious application of RNAi effectors. Such therapies are envisaged to curtail HTR1B expression in pathological states where receptor hyperactivity is demonstrably detrimental. The successful clinical translation of these HTR1B-targeting RNAi strategies, however, is critically contingent upon the continued innovation and implementation of highly efficient and specific delivery platforms. Consequently, considerable research impetus remains focused on optimizing advanced delivery vehicles, such as tailored lipid nanoparticle (LNP) formulations and sophisticated, often tissue-tropic, viral vector systems.
Creative Biolabs offers gene therapy development services using promoter elements. A cornerstone of developing effective and safe HTR1B-targeted gene therapies lies in the sophisticated engineering of expression cassettes. These constructs must incorporate highly selective cis-regulatory elements, principally tissue-specific or cell-type-specific promoters, to meticulously govern the spatial and temporal dynamics of HTR1B transgene expression exclusively within designated anatomical regions or desired cellular populations. Such precise control over expression is, perhaps, critically important for substantially mitigating the risk of adverse events that could arise from ectopic HTR1B activity in non-target tissues.
Creative Biolabs offers comprehensive and innovative services to drive the development of HTR1B cell therapy. Please for more services.
Creative Biolabs offers organoids models development services. These sophisticated three-dimensional culture systems are proving instrumental for meticulously dissecting the putative contributions of HTR1B signaling pathways to the complex etiology and pathogenesis of various neurodevelopmental disorders. This crucial capability consequently renders them an invaluable platform, not merely for fundamental mechanistic investigations into HTR1B function, but also, perhaps, as a human-relevant system for the preclinical evaluation and optimization of novel cellular therapeutic strategies aimed at these challenging conditions.
Creative Biolabs offers ex vivo tissue models development services. The elucidation of HTR1B receptor function and the concurrent preclinical assessment of associated therapeutic interventions are significantly bolstered by the utilization of acute ex vivo tissue preparations. These experimental models, typically involving viable brain slices meticulously procured from neuroanatomically pertinent regions, present distinct methodological advantages over more reductionist approaches.
Creative Biolabs is a leading specialty CRO providing state-of-the-art platforms in membrane protein preparation to our worldwide clients. Our scientific team offers not only regular membrane protein preparation services but also customized services based on the requirements of our clients, with a great value service with exceptional quality and rapid reporting. Please feel free to for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
