Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | 5-hydroxytryptamine receptor 5A |
| Gene Name | HTR5A |
| Uniprot | P47898 (Human); P30966 (Mouse) |
| Synonym | 5-HT5A; 5-HT-5; 5-HT-5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled |
| Background | 5-hydroxytryptamine receptor 5A (HTR5A), alternatively called serotonin receptor 5A, is a multi-pass membrane protein that belongs to the 5-hydroxytryptamine receptor family. Only the HTR5A subtype is expressed in human brain and it is encoded by HTR5A gene. Within the CNS (central nervous system), HTR5A shows a relatively broad distribution in human brain, including the cerebral cortex, thalamus, hypothalamus, hippocampus, habenula, cerebellum, and spinal cord. The HTR5A receptor has been supposed to be functional in a native expression system. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX343 | NativeExtract™ Human HTR5A Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3441K | MemDX™ Membrane Protein Human HTR5A Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0535X | MemDX™ Membrane Protein Human HTR5A (5-hydroxytryptamine receptor 5A) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP1149J | MemDX™ Membrane Protein Human HTR5A (5-hydroxytryptamine receptor 5A expressed in HEK293T) for Antibody Discovery | HEK293 cells | Full length | N/A |
| Please for more products or customization | ||||
H***ah: The protein arrived in perfect condition, with no signs of degradation or damage. The packaging was excellent, ensuring that the protein remained stable and intact during shipping.
19/Nov/2023
R**y: I had a good experience with the HTR5A protein from Creative Biolabs. The protein was delivered on time and was well-packaged. I was able to use it in my experiments without any issues.
07/Aug/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers phosphoproteomic analysis to identify downstream pathways development services. To precisely elucidate the molecular adaptations instigated by pharmacological agents, researchers can effectively leverage phosphoproteomic analyses. This sophisticated methodology offers a comprehensive window into the dynamic landscape of protein phosphorylation. This rigorous biochemical interrogation is instrumental in uncovering the precise mechanisms by which such agents exert their cellular effects, thereby potentially revealing novel therapeutic targets or contributing to the rational design of more effective anti-cancer strategies.
Creative Biolabs offers genotyping and association analysis services. To address this, genotyping techniques offer a powerful means to meticulously characterize an individual's genomic landscape. Specifically, a focused investigation into single-nucleotide polymorphisms (SNPs) within candidate genes, such as the HTR5A locus, can reveal crucial associations. Such analyses could potentially unveil novel genetic determinants influencing lipid metabolism. It is important to acknowledge that while a robust association may be identified, further functional studies would be required to definitively establish a causal relationship and elucidate the underlying biological mechanisms by which these genetic variations influence the observed phenotype.
Creative Biolabs offers EMSA services. To investigate how specific genetic variations influence transcriptional control, Electrophoretic Mobility Shift Assays (EMSAs) represent a robust and widely utilized biochemical technique. This method is particularly effective for analyzing DNA-protein interactions within regulatory regions of the genome. In the context of the HTR5A gene, a compelling application of EMSA involves employing nuclear extracts derived from relevant cell lines. These extracts contain a rich repertoire of transcription factors and other DNA-binding proteins. Concurrently, biotin-labeled oligonucleotide probes are meticulously synthesized. These probes are designed to encompass specific single-nucleotide polymorphisms (SNPs) within the HTR5A promoter region, representing both common and variant allelic forms.
Creative Biolabs offers comprehensive and innovative services to drive the development of HTR5A cell therapy. Please for more services.
Creative Biolabs offers sphere-forming assay services to assess tumor-initiating cells. Elucidating the functional significance of specific genetic targets within the complex milieu of tumor biology is a cornerstone of modern cancer research. In this endeavor, sphere-forming assays emerge as an invaluable in vitro methodology, particularly for assessing the impact of novel therapeutic agents on tumor-initiating cells (TICs). These assays leverage the inherent capacity of TICs, also known as cancer stem cells, to proliferate and form non-adherent, three-dimensional cellular aggregates, or "tumor spheres," under specific serum-free culture conditions. This quantitative assessment provides a direct measure of the agents' capacity to suppress the self-renewal and proliferative potential of these critical tumor subpopulations.
Creative Biolabs offers next-generation sequencing services for genotype characterization. In the context of developing HTR5A knockout cell lines, the comprehensive application of NGS offers a high-resolution window into the resulting genetic modifications. This advanced sequencing capability allows for the precise determination of the entire genotype of these engineered cellular constructs. By comparing the genomic landscape of the knockout cells to their wild-type counterparts, researchers can definitively confirm the intended disruption of the HTR5A gene, simultaneously gaining profound insights into the precise genetic changes that have occurred. This meticulous genomic interrogation is crucial for understanding the direct and indirect impact of HTR5A loss on fundamental cellular functions, potentially revealing compensatory mechanisms or novel downstream effects.
Membrane protein preparation in Creative Biolabs can be exploratory or more extensive to meet your specific requirements. With thoroughly understanding, we provide the largest and most diverse portfolio of standard and custom professional membrane protein preparation services. Please feel free to for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
