Introduction of KCNS2
KCNS2, potassium voltage-gated channel subfamily S member 2 is a protein that in humans is encoded by the KCNS2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. This potassium channel subunit does not form functional channels by itself, but it can form functional heterotetrameric channels with KCNB1 and KCNB2 to modulate the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
|Basic Information of KCNS2|
|Protein Name||Potassium voltage-gated channel subfamily S member 2|
|Aliases||Delayed-rectifier K(+) channel alpha subunit 2, Voltage-gated potassium channel subunit Kv9.2, KIAA1144|
|Organism||Homo sapiens (Human)|
Function ofKCNS2 Membrane Protein
KCNS2 gene was identified and cloned in 1997, and it is located in the 8q22 region of the chromosome. It’s colocalized with Kv2.1 and/or Kv2.2 alpha subunits in several regions of the brain. Neither Kv9.1 nor Kv9.2 has K+ channel activity by themselves, but both modulate the activity of Kv2.1 and Kv2.2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values. In later researches, it has been reported that Kv9.2 mutations were identified in Essential Tremor, early-onset essential tremor, human Neuroblastoma, rat pulmonary arteries. They show the potential function of Kv9.2 in these diseases. In addition, Kv9.1 may have a functional role in neural proliferation. Also, mutations in Kv9.1 is associated with the development of Essential Tremor. Furthermore, it plays a critical role in HPV infection in rat, mainly in small pulmonary arteries.
Fig.1 Model 3D protein structure of KCNS2. (Liu, 2016)
Application of KCNS2 Membrane Protein in Literature
This article identified a mutation of KCNS2 in a family with Essential Tremor, and then validated the function in a drosophila model, and demonstrated KCNS2’s role in ET disease.
This article identified candidate genes including KCNS2 (KV9.2), HAPLN4 (BRAL2) and USP46 which were highly expressed in the cerebellum and Purkinje cells, and influence function of the gamma-amino butyric acid (GABA)-ergic system.
This study showed the possible interaction of tau with Kv channels - the tau-mediated alteration of Kv channels could be involved in its action on neural proliferation.
This article showed that overexpression of tau declined the mRNA levels of Kv channels and related currents. The effects of tau overexpression on Kv channels provided an alternative explanation for low sensitivity to anti-cancer chemicals in some specific cancer tissues.
This article identified and fully sequenced a rat Kv9.2 cDNA through investigating the expression of delayed rectifying (Kv) channel mRNA in rat main and small pulmonary arteries. It may play a role in HPV infection.
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