Potassium voltage-gated channel subfamily S (KCNS protein family) belongs to the big family of voltage-gated potassium channels (VGKCs), which consists of transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane. They form the largest and most diversified class of ion channels and play a crucial role in returning the depolarized cell to a resting state. Until now, three members of the KCNS protein family have been identified, namely potassium voltage-gated channel subfamily S member 1, potassium voltage-gated channel subfamily S member 2, and potassium voltage-gated channel subfamily S member 3. Studies have shown that the expression of KCNS proteins can be found in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials.
Here, we have described in detail of members of the KCNS protein family, including potassium voltage-gated channel subfamily S member 1, potassium voltage-gated channel subfamily S member 2, and potassium voltage-gated channel subfamily S member 3. To learn more detailed information, please click the links below.
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