Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsLarge neutral amino acids transporter family is also known as solute carrier family 43 (SLC43 family), which is a group of integral membrane proteins belonging to solute carrier superfamily. The large neutral amino acids transporter family consist of only three genes that encode the transporters with system L amino acid transporter activity including LAT3 (SLC43A1), LAT4 (SLC43A2), and the orphan protein EEG1 (SLC43A3). SLC43A1 and SLC43A2 contain 12 putative transmembrane domains with both N and C termini located intracellularly. They are the Na+ and Cl- -independent neutral amino acid transporters with two kinetic components. SLC43A1 has been required for podocyte development and function. Besides, SLC43A1 transports branched-chain amino acids (BCAAs) from liver and skeletal muscle to the bloodstream. SLC43A2 may be involved in the transportation of BCAAs from mother to fetus. However, the physiological roles of EEG1 are not clear.
Here shows part of the SLC43 family in humans including SLC43A1 and SLC43A2, encoded by SLC43A1 and SLC43A2 genes, respectively. SLC43A1 is abundantly expressed in human tissues including pancreas, liver, skeletal muscle and fetal liver. SLC43A2 is most expressed in the placenta, kidney and peripheral blood leukocytes Although the mechanism of transport of SLC43A1 and SLC43A2 is known, their physiological roles still remain quite obscure.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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