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Magic™ Anti-GPCR Antibody Production

With rich experience in antibody and GPCR research, excellent experts from Creative Biolabs offer services from all aspects about antibody targeting GPCR by Magic™ platform.

G-protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins, and they represent a major therapeutic target class. Many marketed drugs exert their effect through modulation of GPCR function, and GPCRs successfully targeted with small molecules. Yet, the number of small new molecular entities targeting GPCRs that have been approved as therapeutics has been limited. With the improvement of immunization-related technologies and advancement of GPCR purification and expression techniques, antibody-based targeting of GPCRs is becoming more and more popular. The discovery of a unique class of heavy chain antibodies (hcAbs) in the sera of camelids may provide novel GPCR-directed therapies. Antigen-binding fragments of hcAbs, also referred to as single domain antibodies, combine the advantages of both small molecules (e.g., molecular cavity binding, low production costs) and monoclonal antibodies (e.g., high affinity and specificity). Single domain antibodies are now useful as therapeutics and also starting to find application as diagnostics and as high-quality tools in GPCR research.

Structural features of different antibodies

With the development of structure biology and biological chemistry, more and more GPCRs are expressed and purified in vitro. However, antibodies targeting GPCR are not easy to gain. Scientists may waste much time in screening and expression of antibodies. To meet the increasing need of customers, excellent team of Creative Biolabs develops the Magic™ platform, we serve for three major independent methods, but are not limited to:

Cell-based Expression
Cell-free Expression
Virus-like Particles (VLPs) and Lipoparticles

Magic™platform has also developed Phage Display Library Screening and hybridoma technique for monoclonal antibody screening and production respectively:

Phage Display Library Screening
Mouse/Rat Hybridoma Production

With rich experiences for hundreds of successful cases by Magic™ platform, Creative Biolabs devotes itself to meeting all service about GPCR antibody. It provides custom anti-membrane proteins antibody production services, which include but are not limited to:

Anti-GPCR antibody
Anti-Ion channels antibody
Anti-Transporters antibody

Chan, C.E.Z., Lim, A.P.C., MacAry, P.A., and Hanson, B.J. (2014). The role of phage display in therapeutic antibody discovery. Int Immunol 26, 649-657.
Mujic-Delic, A., de Wit, R.H., Verkaar, F., and Smit, M.J. (2014). GPCR-targeting single domain antibodies: attractive research tools, diagnostics, and therapeutics. Trends Pharmacol Sci 35, 247-255.

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