Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs has established advanced phage display platform for the selection of binders with high specificity and affinity. Our scientists have developed a variety of screening strategies for the identification of natural polymer binding peptides. We are pleased to share our cutting-edge technology and extensive expertise to facilitate our clients’ project development on natural polymers.
The Background of Natural Polymers as Substrates of Phage Display
Phage display technology has been utilized as a powerful tool for the selection of ligands for many biological molecules. In the case of peptides, the power of the phage displayed peptide libraries arose from the diversity of peptide sequences which have been demonstrated in numerous studies. Researchers have identified cyclic peptides and linear peptides, which are good binders to chitin. These biocompatible networks established were proposed as possible scaffold materials for tissue engineering. A variety of cellulose derivatives have also been used as target substrates for the identification of peptide binding ligands. A variety of heptapeptides can use microcrystalline cellulose as the substrate. A crystalline cellulose nanowhisker binding peptide, which was predominantly composed of aromatic residues (WHWTYYW), was also isolated. Peptide binders to fibrous cellulose as well as to carbon black were then identified using phage display technology.
Fig. 1 A triblock fusion construct composed of a central, rigid and hydrophilic interdomain linker flanked by cellulose and carbon black binding peptide ligands allows the deposition of carbon black particles onto paper surfaces (Günay and Klok 2015).
Creative Biolabs has established the high-throughput phage display platform to identify binders with high specificity and affinity. Combined this advanced platform, natural polymers binding peptides in the enriched sublibrary can be identified efficiently and effectively. We can offer binding peptides identification services on a variety of natural polymers, including but not limited to chitin, cellulose, cellulose nanowhiskers, and carbon black.
Key Advantages of Natural Polymers Binding Peptides Identification Service
In terms of the extensive experience in phage display technology, Creative Biolabs is proud to offer our clients a series of phage selection services with the best quality and most competitive price. We can offer high-quality customized services by adjusting protocols for natural polymers binding peptides identification. For more detailed information, please feel free to contact us or directly send us an inquiry.