As an industry leader specialized in custom services, Creative Biolabs has commercialized a full range of innovative integrated services that are based on phage display technology. Creative Biolabs has developed a high-throughput phage display libraries analysis platform for peptide ligands identification. We have a variety of strategies to define and identify target-binding peptides for soft matter, including polymers, as well as small organic molecules and inorganic molecules.
The Background of Soft Matters as Substrates of Phage Display
Phage display has been widely used for drug discovery and vaccine development, it also can be used to analyze the energetics at the binding interfaces of proteins and to map the molecular diversity of receptors in the human vasculature. Since its first successful implementation by George P. Smith in 1985, phage display has evolved into a powerful method for the identification of natural or novel ligands to a myriad of biological substrates including enzymes, toxins, receptors and structural proteins. This technique has been expanded. It has been increasingly used for the identification of small peptide sequences that bind to solid substrates, such as metals, ceramics, and carbon-based materials. Nowadays, it is exciting that the substrates have been expanded to soft matter, including polymers, as well as small organic molecules. Small peptides identification is attractive in finding building blocks to functionalize or to modulate the properties of surfaces and interfaces. They can be conjugated with biomolecules, polymers or nanoparticles for selective functionalization of the substrate of interest. It could be beneficial for the development of sensors, templates for mineralization, as well as electronic devices.
Fig.1 Phage display is a powerful tool allowing the identification of peptide ligands to synthetic polymers, small organic molecules and natural polymers (Günay & Klok, 2015).
Creative Biolabs can provide high-quality service of identification of binding peptides for synthetic or natural polymers, as well as inorganic and organic molecules. After identification of the hits, we also determine the affinity of the identified ligands to soft matter, by the service of Characterization of the Affinity of Identified Peptides to Soft Matters.
Equipped with the state-of-the-art platforms and professional scientific staff, Creative Biolabs has long-term devoted to the development and application of phage display technology. Creative Biolabs can provide the best service for the identification peptide sequences, which are able to bind with high affinity and selectivity to soft matter surfaces, by tailored our variety of strategies. For more detailed information, please feel free to contact us or directly send us an inquiry.