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HighlightsIntroduction of NMUR2
NMUR2 is encoded by NMUR2 gene which is localized on chromosome 2q34-937 in human. It belongs to the G-protein-coupled receptor (GPCR) family which has been extensively studied because it offers numerous possibilities for therapeutic applications. Together with NMUR1, they are two receptors for neuromedin-U. Slightly longer than NMUR1, human NMUR1 consists of 412 amino acids with the predicted molecular mass of 47,450 Da. The expression of NMUR2 is predominant in the central nervous system. The human NMUR2 mRNA is confined predominantly in the brain, especially in the spinal cord, medulla oblongata, thalamus, substantia nigra, and pontine reticular formation.
| Basic Information of NMUR2 | |
| Protein Name | Neuromedin-U receptor 2 |
| Gene Name | NMUR2 |
| Aliases | FM4, FM-4, TGR1, NMU2R, TGR-1, NMU-R2 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9GZQ4 |
| Transmembrane Times | 7 |
| Length (aa) | 415 |
| Sequence | MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT |
Function of NMUR2 Membrane Protein
Neuromedin U is a structurally highly conserved neuropeptide, which is involved in a series of functions that include smooth-muscle contraction, controlling the ion transport and blood flow in the intestine, and regulation of adrenocortical functions. The NMUR2 which is found in the central nervous system might be responsible for mediating the anorectic effects of NMU. It has been reported that the NMUR2 selective PEGylated NMU-8 analogues would be helpful for the elucidation of physiological functions of the NMU/NMUR2 system. In addition, the design and synthesis of NMUR2-selective agonist play an important role in the treatment of diabetes and obesity.
Fig.1 Structure of NMUR2 membrane protein. (Brighton, 2004)
Application of NMUR2 Membrane Protein in Literature
Authors in this group design and synthesize an NMUR2 selective PEGylated NMU-8 analogues present functions to lose weight and inhibit food intake. In addition, it would be helpful to elucidate the physiological function of the NMU/NMUR2 system.
NMUR2 has been always considered as a promising treatment option for diabetes and obesity. This article reveals that the octadecanoyl analog with amino acid substitutions with a linker dramatically enables the improvement of NMUR2 selectivity and also remains the high agonist activity.
This article reports that NMUR1 selective agonist can be a benefit for the treatment of obesity and diabetes, while the NMUR2 selective agonist can be served as the well-balanced drug for the treatment of obesity.
NMU is the highly conserved neuropeptide which enables the regulation of food intake and body weight. NMUR2 found in the central nervous system might be responsible for mediating the anorectic effects of NMU. This article reveals that NMUR2 signaling in PVN regulates the consumption and preference for high-fat foods.
NMU and NMS are structurally related neuropeptides which enable the modulation of energy homeostasis. NMUR1 and NMUR2 are two high-affinity NMU/NMS receptors. This article characterizes NMUR2-deficient mice to evaluate the role of NMUR2 in the regulation of energy homeostasis.
NMUR2 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-NMUR2 antibody development services.
Creative Biolabs is one of the well-recognized experts who are professional in the field of membrane protein discovery. As a forward-looking research institute as well as a leading custom service provider in the world, we are able to provide the custom services to meet the specific needs of our clients. If you are interested in our services, please feel free to contact us for more information.
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