Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y10 |
| Gene Name | P2RY10 |
| Uniprot | O00398 (Human); Q8BFU7 (Mouse) |
| Synonym | P2Y10; LYPSR2; putative P2Y purinoceptor 10; G-protein coupled purinergic receptor P2Y10; P2Y-like receptor; purinergic receptor P2Y, G-protein coupled, 10; purinergic receptor P2Y10 |
| Background | P2RY10, also known as P2Y receptor family member 10, purinergic receptor P2Y, purinergic receptor P2Y10, P2Y-Like receptor, G-protein coupled purinergic receptor P2Y10, or LYPSR2, is a G-protein coupled receptor (GPCR) protein and has a molecular weight of 38.8 kDa. In humans, it is encoded by the gene P2RY10 which resides on the chromosome Xq21.1. And there exists a pseudogene for P2RY10 nearby on the chromosome X. This receptor is a member of the purine and pyrimidine nucleotide receptor family that is coupled to G proteins. Multiple alternatively spliced transcripts of P2RY10 gene have been observed. P2RY10 associated pathways are signaling by GPCR and peptide ligand-binding receptors. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX78 | NativeExtract™ Human P2RY10 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3380K | MemDX™ Membrane Protein Human P2RY10 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0991X | MemDX™ Membrane Protein Human P2RY10 (P2Y receptor family member 10) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
I***de: Creative Biolabs' P2RY10 exhibits excellent batch-to-batch consistency and native conformation, enabling reliable ligand binding assays in atherosclerosis mechanistic studies.
18/Oct/2023
J***a: Their gene-to-vial service delivered Gq-coupled active P2RY10 in 6 weeks, including full glycosylation profiling and thermostability validation critical for drug discovery pipelines.
27/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Silencing for P2RY10 Pathway Modulation
Creative Biolabs offers gene silencing services. Gene-editing technology enables precise disruption of P2RY10 signaling, a purinergic receptor implicated in cancer immune evasion and inflammatory disorders. By designing guide RNAs complementary to exonic regions of P2RY10, researchers can induce frameshift mutations to abrogate receptor function. For example, in glioblastoma models, P2RY10 knockout enhanced T-cell infiltration and suppressed tumor growth by attenuating adenosine-mediated immunosuppression. Creative Biolabs' end-to-end gene editing services, including optimized RNA design and in vivo delivery systems, ensure robust target validation for therapeutic development.
AAV-Delivered Dominant-Negative P2RY10 Constructs for Chronic Inflammation
Creative Biolabs offers AAV-delivered dominant-negative P2RY10 constructs services. Adeno-associated virus (AAV) vectors engineered to express dominant-negative P2RY10 variants represent a promising strategy for conditions like rheumatoid arthritis. These constructs competitively inhibit endogenous receptor dimerization, blocking downstream pro-inflammatory signaling cascades. Preclinical studies in collagen-induced arthritis models demonstrated that intra-articular AAV delivery reduced synovial inflammation by 60% compared to controls. Creative Biolabs' proprietary AAV serotype libraries enable tissue-specific targeting, ensuring high transduction efficiency in immune cells or joint tissues.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY10 cell therapy. Please for more services.
CAR-T Cells Engineered with P2RY10 Antagonists for Solid Tumors
Creative Biolabs offers development services for CAR-T cells engineered with P2RY10 antagonists. Chimeric antigen receptor (CAR)-T cells modified to secrete P2RY10-blocking antibodies can overcome adenosine-rich tumor microenvironments. In melanoma xenografts, these dual-function CAR-T cells reduced extracellular adenosine levels by 80% while maintaining cytotoxic activity, achieving sustained tumor regression. Creative Biolabs' immunofluorescence-based platforms validate receptor colocalization and therapeutic efficacy, accelerating translational pipelines.
Hematopoietic Stem Cell (HSC) Therapy with P2RY10 Overexpression for Autoimmunity
Creative Biolabs offers HSC therapy development services. HSCs engineered to overexpress P2RY10 via lentiviral vectors have shown potential in modulating autoimmune responses. Overactive P2RY10 in regulatory T cells (Tregs) enhances immunosuppressive adenosine production, restoring immune tolerance. In Type 1 diabetes murine models, transplanted P2RY10-modified HSCs reduced pancreatic β-cell destruction by 45%. Creative Biolabs' RNA sequencing services provide critical insights into transcriptional dynamics during HSC differentiation.
The complexities of P2RY10 biology demand tailored strategies, from gene editing to advanced cell engineering. Creative Biolabs' integrated solutions—spanning viral vector design, in vivo validation, and high-resolution imaging—empower researchers to accelerate target validation and preclinical testing. to explore how our cutting-edge platforms can de-risk your P2RY10-focused therapeutic pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
