Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y12 |
| Gene Name | P2RY12 |
| Uniprot | Q9H244 (Human); Q9CPV9 (Mouse) |
| Synonym | HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc); P2Y purinoceptor 12; ADP-glucose receptor; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; P2Y12 platelet ADP receptor; purinergic receptor P2RY12; purinergic receptor P2Y, G-protein coupled, 12; putative G-protein coupled receptor |
| Background | P2RY12, also known as purinergic receptor P2RY12, purinergic receptor P2Y12, purinergic receptor P2Y, P2Y(AC), P2Y(12)R, HORK3, BDPLT8, putative G-protein coupled receptor, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, is a member of G-protein coupled receptors (GPCR) family, which has some receptor subtypes with different pharmacological selectivity. It is a 39.4 kDa molecule and in humans, encoded on the chromosome 3q25.1. Initially, the P2RY12 gene is reported that contains at least 2 exons, in charge of coding for 342 amino acid all length protein and separated by a 1,700 bp intron, localized upstream of the ATG codon. There are two transcript variants coding for the same isoform that have been identified for the P2RY12 gene. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX76 | NativeExtract™ Human P2RY12 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| S01YF-0622-KX91 | MemDX™ Recombinant Human P2RY12 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cell | Full length | VLPs |
| MP1365J | MemDX™ Membrane Protein Human P2RY12 (Purinergic receptor P2Y12) expressed in E.coli for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| MP0636J | MemDX™ Membrane Protein Human P2RY12 (Purinergic receptor P2Y12) for Antibody Discovery | HEK293 cell | Full length | N/A |
| Please for more products or customization | ||||
With our advanced cell line construction platform and extensive experience, we offer you high-quality and highly stable membrane protein stable cell lines to support your research and drug development.
| CAT# | Product Name | Target Species | Host Cell |
| S01YF-1022-KX578 | MemDX™ Human FLAG tagged P2RY12 1321N1 Cell Line, Calcium flux assay | Human | 1321N1 |
| S01YF-1022-KX579 | MemDX™ Rat FLAG tagged P2RY12 CHO dhfr- Cell Line, Calcium flux assay | Rat | CHO dhfr- |
| Please contact us for more products or customization | |||
I***go: Creative Biolabs' P2RY12 exhibits exceptional purity and receptor activity retention, ideal for GPCR binding assays.
22/Sep/2023
R**y: Tailored P2RY12 variants were delivered in 4 weeks with optimized mammalian expression.
13/Mar/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Adenoviral Vector-Mediated P2RY12 Silencing in Platelet Hyperactivation
Creative Biolabs offers adenoviral vector-mediated P2RY12 silencing services. Recent advancements in gene silencing technologies have enabled targeted modulation of P2RY12 expression to mitigate thrombotic risks. For instance, adenoviral vectors engineered to deliver small interfering RNA (siRNA) sequences directly to megakaryocyte precursors in bone marrow can selectively suppress P2RY12 transcription, thereby reducing ADP-mediated platelet aggregation. This approach, validated in preclinical models, demonstrates a 60% reduction in thrombus formation without compromising hemostasis. Creative Biolabs' proprietary viral vector platforms optimize delivery efficiency through lineage-specific promoters, ensuring precise targeting of hematopoietic stem cells. Such strategies are particularly promising for patients with genetic polymorphisms associated with hyperreactive P2RY12 signaling.
Gene Editing for P2RY12 Loss-of-Function Mutations
Creative Biolabs offers gene editing services. Genome editing offers a permanent solution for individuals with gain-of-function P2RY12 variants. By introducing frameshift mutations in exon 3 of the P2RY12 gene, platelet surface receptor density is reduced by >80%, as evidenced in ex vivo platelet reactivity assays. Creative Biolabs' gene-editing screening services incorporate RNA sequencing to validate editing specificity, minimizing off-target effects. This method aligns with emerging clinical trends emphasizing genotype-guided antithrombotic therapy.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY12 cell therapy. Please for more services.
Macrophage-Specific P2RY12 Inhibition via Lentiviral Transduction
Creative Biolabs offers macrophage-specific P2RY12 inhibition development services. P2RY12's newly identified role in macrophage iron metabolism and atherosclerosis underscores the potential of engineered macrophages to modulate plaque stability. Lentiviral vectors encoding dominant-negative P2RY12 constructs can be transduced into autologous macrophages, disrupting ADP-mediated iron efflux pathways. In murine models, this intervention reduced atherosclerotic lesion size by 45% by normalizing intraplaque iron homeostasis. Creative Biolabs' lentiviral toolkit includes myeloid-specific promoters (e.g., CD68) to restrict transgene expression, a critical safety consideration for clinical translation.
CAR-T Cell Targeting of P2RY12-Expressing Vascular Stromal Cells
Creative Biolabs offers CAR-T cell targeting of P2RY12-expressing vascular stromal cells development services. Chimeric antigen receptor (CAR)-T cells redesigned to recognize P2RY12 epitopes on activated vascular smooth muscle cells (VSMCs) have shown efficacy in stabilizing high-risk atherosclerotic plaques. These CAR-T cells secrete matrix-stabilizing cytokines (e.g., TGF-β1) while selectively eliminating pro-inflammatory VSMCs, achieving a 30% reduction in plaque rupture incidence in primate trials. Creative Biolabs' cell culture systems ensure reproducible expansion of CAR-T populations with >95% receptor specificity, a cornerstone for scalable manufacturing.
The development of P2RY12-targeted therapies demands rigorous molecular validation and translational expertise. Creative Biolabs' integrated service portfolio—spanning high-content immunofluorescence imaging for receptor localization studies, AAV/lentiviral vector customization, and CAR-T therapeutic development—provides an unmatched foundation for accelerating your drug discovery pipeline. to explore collaborative solutions tailored to your preclinical and clinical milestones.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
