Presenilin Family

Presenilin family is a group of related transmembrane proteins that contain nine transmembrane domains, with a large loop between the sixth and seventh. There are two presenilins in vertebrates, referred to as presenilin-1 (PS-1, encoded by PSEN1 gene in humans) and presenilin-2 (PS-2, encoded by PSEN2 gene in humans). Presenilins constitute the catalytic subunits of the γ-secretases, which are membrane-embedded aspartyl protease complexes responsible for generating the carboxyl terminus of the amyloid β-protein (Aβ) from the amyloid protein precursor (APP). Presenilins were primarily found to be sites of missense mutations responsible for early-onset Alzheimer disease (AD). Presenilins undergo cleavage in an alpha-helical region of one of the cytoplasmic loops to produce a large N-terminal and a smaller C-terminal fragment that together form part of the functional protein.

Mutations in the presenilin genes are considered to account for about 20–25% of all familial AD cases. Presenilins are also suggested to be involved in the modulation of intracellular Ca²⁺ which plays a part in presynaptic neurotransmitter release and long-term potentiation induction. Here, the two members of the presenilin family are covered in further detail for your review.

Human Presenilin Members

Based on our Magic™ membrane protein production platform, scientists at Creative Biolabs are experts in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Furthermore, our Magic™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

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