SLC13A2 Membrane Protein Introduction

Introduction of SLC13A2

SLC13A2 belongs to the solute carrier family 13 that includes transporters for di- and tricarboxylates as well as sulfate. SLC13A2 seems to play a crucial role in the regulation of urinary citrate concentrations. And low urinary citrate concentrations or hypocitraturia are usually associated with an increased risk of kidney-stone formation. Moreover, SLC13A2 may also affect longevity or metabolic status.

Basic Information of SLC13A2
Protein Name Solute carrier family 13 member 2
Gene Name SLC13A2/ NADC1/SDCT1
Aliases Na(+)/dicarboxylate cotransporter 1 (NaDC-1), Renal sodium/dicarboxylate cotransporter
Organism Homo sapiens (Human)
UniProt ID Q13183
Transmembrane Times 12
Length (aa) 592

Function of SLC13A2 Membrane Protein

SLC13A2/NaDC2 is an important protein in human. This protein influences cotransport of sodium ions and dicarboxylates such as succinate and citrate. It also participates in many molecular functions, including low-affinity sodium (dicarboxylate symporter activity) and transporter activity. Anion transmembrane transport activity is an important biological progress under the direction of SLC13A2.

Schema for the metabolism of citrate in a proximal tubule cell. Fig.1 Schema for the metabolism of citrate in a proximal tubule cell. (Dogliotti, 2013)

Application of SLC13A2 Membrane Protein in Literature

  1. Rendina D., et al. Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers. J Nephrol. 2017, 30(3):411-418. PubMed ID: 27639591

    This article identifies that there is an epistatic interaction between VDR and SLC13A2 alleles in the pathogenesis of idiopathic hypocitraturia in calcium-oxalate SF.

  2. Lee H.W.T., Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney. Am J Physiol Renal Physiol. 2017, 312(3):F427-F435. PubMed ID: 27927654

    This article suggests that in the human kidney, apical NaDC1 immunolabel is presented throughout the entire proximal tubule and is not detectable in other renal cells; NaDC1 immunolabel is not presented in renal tumors. These results provide important information regarding NaDC1's role in human dicarboxylate metabolism.

  3. Pattarin U., et al. rs11567842 SNP in SLC13A2 gene associates with hypocitraturia in Thai patients with nephrolithiasis. Genes & Genomics. 2018, 40(9):965-972.

    This review shows that patients with AA genotypes are more susceptible to hypocitraturia than those with GG, hence carrying a higher risk for kidney stone recurrence.

  4. Basaran E., et al. Evaluation of rs11568476 mutation of SLC13A2 gene in individuals with hypocitraturia and calcium-containing kidney calculi. European Association of Urology. 2017, 16(5): e2187.

    This article shows the present results are not able to demonstrate rs11568476 mutation of SLC13A2 gene as a possible genetic factor for development of hypocitraturia in patients with calcium containing kidney renal stone disease.

SLC13A2 Preparation Options

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  1. Dogliotti E, et al. (2013). Nutrition in calcium nephrolithiasis. J Transl Med. 11(1), 1-4.

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