Solute Carrier Family 13

The solute carrier family 13 (SLC13) consists of five structurally related proteins (SLC13A1-5) that have been identified in a variety of animals, plants, yeast, and bacteria. They are characterized by a central core domain encompassing from eight to thirteen transmembrane a-helices flanked by an intracellular N-terminus and an extracellular C-terminus that contains putative consensus glycosylation sites. Based on substrate specificities, the family is divided into two distinct groups: the Na⁺-sulphate (NaS) cotransporters and the Na⁺-carboxylate (NaC) cotransporters. Studies have shown that SLC13 family is extensively expressed in diverse tissues, including kidney, small intestine, liver, placenta, and brain. In addition, SLC13 transporters mediate Na⁺ -coupled anion substrate movement across the plasma membrane of the cells and are electrogenic, generally with a Na⁺: substrate coupling ratio of 3:1.

Here, we have described in detail of members of the SLC13 family, including but not limited to SLC13A1, SLC13A2, and SLC13A3. To learn more detailed information, please click the links below.

Human SLC13 Members

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