The solute carrier family 13 (SLC13) consists of five structurally related proteins (SLC13A1-5) that have been identified in a variety of animals, plants, yeast, and bacteria. They are characterized by a central core domain encompassing from eight to thirteen transmembrane a-helices flanked by an intracellular N-terminus and an extracellular C-terminus that contains putative consensus glycosylation sites. Based on substrate specificities, the family is divided into two distinct groups: the Na⁺-sulphate (NaS) cotransporters and the Na⁺-carboxylate (NaC) cotransporters. Studies have shown that SLC13 family is extensively expressed in diverse tissues, including kidney, small intestine, liver, placenta, and brain. In addition, SLC13 transporters mediate Na⁺ -coupled anion substrate movement across the plasma membrane of the cells and are electrogenic, generally with a Na⁺: substrate coupling ratio of 3:1.
Here, we have described in detail of members of the SLC13 family, including but not limited to SLC13A1, SLC13A2, and SLC13A3. To learn more detailed information, please click the links below.
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