Introduction of TACR1
TACR1 (Tachykinin receptor1), also known as substance P (SP) receptor or NK-1 receptor, is encoded by TACR1 gene. It is a member of the G-protein-coupled receptor (GPCR) family, which consists of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus, and a cytoplasmic carboxy-terminus. It’s commonly used to regulate local and systemic inflammatory processes, and many studies conducted in TACR1 reveal that it is a promising molecular diagnostic marker and novel therapeutic targets in the clinic.
|Basic Information of TACR1|
|Protein Name||Tachykinin receptor 1|
|Organism||Homo sapiens (Human)|
Function of TACR1 Membrane Protein
The TACR1 receptor can be found in various immune cells, like gastrointestinal tracts, thyroid gland, and present in neurons. It preferentially binds to the SP, which indicates that plays an important role in many functions, such as, the stress and pain transmission signal, the contraction of smooth muscles and inflammation. The TACR1 receptor has also been studied in bipolar disorder, attention deficit hyperactivity disorder (ADHD), alcoholism and opioid addiction. Besides, many diseases also have been proved to be related to the TACR1 receptor (NK-1 receptor), including asthma, rheumatoid arthritis and gastrointestinal disorders. The TACR1 receptor antagonists have been applied to several pathophysiological models of anxiety and depression.
Fig.1 Structure of TACR1 membrane protein.
Application of TACR1 Membrane Protein in Literature
This article reports that the role of NK-1R in VZV-infected primary human spinal astrocytes (HA-sps) to shed light on the pathogenesis of VZV myelopathy.
This article reveals that how the substance P induced cell proliferation in both acute myeloid leukemia cell lines, and the function of four different Neurokinin-1 receptor antagonists in the potential treatment of human acute myeloid leukemia.
Authors select six SNPs of Genotype data, which cover most variation in the TACR1 gene, to test for an association with symptomatic OA. Some sites are associated with a decreased risk of symptomatic OA.
This article report that neuroblastoma cell lines can express TACR1 and this targeting TACR1 activity significantly reduces cell viability and finally induces apoptosis in neuroblastoma cell lines.
Authors conducted a genome-wide association study in several case-control samples of BPAD, alcohol dependence syndrome (ADS) and attention-deficit hyperactivity disorder (ADHD). Several alleles which were founded in these diseases suggest a common molecular pathophysiology.
TACR1 Preparation Options
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