Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsTachykinin receptors are receptors that bind to the tachykinins, which are a family of structurally-related neuropeptides that derive from alternate gene processing. In mammals, the major tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). These tachykinins interact with three neurokinin G protein-coupled receptors: NK1, NK2, and NK3. Moreover, they have exhibited a lack of selectivity to their receptors. All tachykinins interact with all the three-receptor subtypes with SP preferring NK1, NKA preferring NK2, and NKB preferring NK3. As a result, tachykinins and their receptors have been shown to elicit a broad spectrum of activities such as powerful vasodilatation, hypertensive action, and stimulation of extravascular smooth muscle, and are known to be involved in a variety of clinical conditions including chronic pain, Parkinson's disease, Alzheimer's disease, depression, rheumatoid arthritis, irritable bowel syndrome, and asthma.
Consequently, antagonists of tachykinin receptors that are selective, potent, and show efficacy in disease models have been developed to treat diseases, such as nausea and vomiting. The therapeutic potential of these receptors has been actively studied and multiple ongoing clinical trials of NKR antagonists are being undertaken. Here, we give an introduction of the currently known information about the signaling, trafficking, and properties of NKRs.
To obtain tachykinin receptors in the solubilized and stabilized functional formats for further in vitro studies of their molecular mechanisms and functions, Creative Biolabs now offers various preparation options using different reconstitution systems, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Our scientists have accumulated years of experience in the applications of these different strategies and approaches, and we will analyze your project on a case-by-case basis in order to find an optimal match suitable for your downstream applications. See Magic™ membrane protein production platform for more information.
Our service package can be tailored to suit your specific requirements. For example, we can discover high-quality antibodies against your membrane antigens with the help of our powerful Magic™ membrane protein antibody discovery platform. We also present DNA immunization service for anti-membrane protein antibody development. Contact us to request more information and discuss your project goals with our seasoned scientists.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
