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Tachykinin Receptor Family

Tachykinin receptors are receptors that bind to the tachykinins, which are a family of structurally-related neuropeptides that derive from alternate gene processing. In mammals, the major tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). These tachykinins interact with three neurokinin G protein-coupled receptors: NK1, NK2, and NK3. Moreover, they have exhibited a lack of selectivity to their receptors. All tachykinins interact with all the three-receptor subtypes with SP preferring NK1, NKA preferring NK2, and NKB preferring NK3. As a result, tachykinins and their receptors have been shown to elicit a broad spectrum of activities such as powerful vasodilatation, hypertensive action, and stimulation of extravascular smooth muscle, and are known to be involved in a variety of clinical conditions including chronic pain, Parkinson's disease, Alzheimer's disease, depression, rheumatoid arthritis, irritable bowel syndrome, and asthma.

Consequently, antagonists of tachykinin receptors that are selective, potent, and show efficacy in disease models have been developed to treat diseases, such as nausea and vomiting. The therapeutic potential of these receptors has been actively studied and multiple ongoing clinical trials of NKR antagonists are being undertaken. Here, we give an introduction of the currently known information about the signaling, trafficking, and properties of NKRs.

Human Tachykinin Receptor Members
TACR1 TACR2 TACR3

To obtain tachykinin receptors in the solubilized and stabilized functional formats for further in vitro studies of their molecular mechanisms and functions, Creative Biolabs now offers various preparation options using different reconstitution systems, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Our scientists have accumulated years of experience in the applications of these different strategies and approaches, and we will analyze your project on a case-by-case basis in order to find an optimal match suitable for your downstream applications. See Magic™ membrane protein production platform for more information.

Magic™ membrane protein production platform – Creative Biolabs

Our service package can be tailored to suit your specific requirements. For example, we can discover high-quality antibodies against your membrane antigens with the help of our powerful Magic™ membrane protein antibody discovery platform. We also present DNA immunization service for anti-membrane protein antibody development. Contact us to request more information and discuss your project goals with our seasoned scientists.

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