Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1) is a multi-pass plasma membrane catalytic pump subunit encoded by ATP1A1 gene, ubiquitously expressed across somatic cell lineages, localized exclusively to outer cell membrane bilayers. Distinct from other P-type ATPase paralogs, ATP1A1 forms heteromeric complexes with beta subunits to mediate ATP-dependent counter-transport of cytoplasmic sodium and extracellular potassium ions, maintaining resting membrane potential and supporting ion-coupled nutrient co-transport cascades. Under steady physiological conditions, basal ATP1A1 catalytic turnover sustains balanced transmembrane cation gradients without depolarization risk. Upon cellular activation or nutrient uptake stimulation, sustained ATP hydrolysis by ATP1A1 replenishes ion gradients to sustain secondary transport and electrical signaling programs. Unlike housekeeping ion pumps with universal cation balancing roles, ATP1A1 carries tissue-wide baseline ion homeostasis functions that cannot be fully replaced by other alpha isoforms, linking ATP catalytic activity to membrane potential-dependent signaling pathways. Loss of functional ATP1A1 collapses sodium-potassium gradients and disrupts nutrient uptake, while enhanced pump activity stabilizes resting cell electrical status, establishing ATP1A1 as a core research target for P-type ATPase biology and ion modulator screening.
ATP1A1 executes ATP-dependent cation transport function embedded within plasma membrane lipid bilayers, utilizing conserved cytoplasmic ATP-binding and ion-translocating transmembrane helices to power alternating sodium export and potassium import cycles. Conserved ion-binding pocket geometry separates its cation substrate spectrum from calcium or proton ATPase paralogs distributed across organelle membranes. ATP1A1-mediated cation gradient formation bridges cellular energy metabolism and secondary co-transport systems, balancing transmembrane electrical potential relative to cellular metabolic activity. ATP1A1 participates in nutrient absorption, volume regulation and membrane potential-dependent signal transmission. Deficient ATP1A1 catalytic activity disrupts transmembrane ion gradients and impairs coupled substrate uptake capacity. Therefore, ATP1A1 represents a pivotal research target for P-type pump study and ion balance regulatory compound screening.
Fig. 1 Mutant ATP1A1 potentiates Src-Ca²⁺ signaling and promotes tumor cell proliferation upon cardiotonic steroid stimulation.1
The biological functions of ATP1A1 are focused on ATP hydrolysis, sodium-potassium gradient generation and cellular electrical balance control:
Creative Biolabs offers high-quality ATP1A1 proteins through optimized expression systems. These products retain native ATP hydrolytic cation transport biological activity, suitable for pump interaction assays and ion modulator screening. All ATP1A1 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered ATP1A1 stable cell lines, including overexpression and blank control models. These cell lines are optimized for P-type pump expression profiling and cation gradient functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting ATP1A1 are developed via advanced antibody engineering technologies, with no cross-reactivity with other P-type ATPase alpha subunits. These antibodies are validated for plasma membrane localization detection and multi-tissue pump expression profiling, and can be combined with beta subunit detection reagents to analyze complete Na+/K+ ATPase heteromeric complexes in somatic cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for ATP1A1 research:
ATP1A1 is the catalytic alpha subunit of plasma membrane Na+/K+ ATPase that hydrolyzes ATP to generate transmembrane sodium-potassium ion gradients.
ATP1A1 acts as a critical link between cellular energy metabolism and transmembrane ion homeostasis, governing membrane potential and nutrient co-transport.
No, all ATP1A1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length ATP1A1 pump subunits, isoform-specific detection antibodies and custom stable cell lines for ion transport research.
ATP1A1 proteins are validated via ATP hydrolytic cation transport functional testing.
