Technical Platforms

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The pace of scientific discovery is driven by the right tools, the right expertise, and a passion for solving complex challenges. At Creative Biolabs, we accelerate discovery through purpose-built platforms developed for scientists. We combine specialized tools with deep technical expertise to solve complex research challenges. Every platform we've engineered focuses on delivering efficient solutions—helping you advance projects faster across antibody discovery, protein engineering, and membrane protein research.

Phage Display Platform

Precision Screening for Target-Specific Binders

Fig.1 Different types of phage display libraries, including various antibody types, peptides and enzymes. (OA Literature) Fig.1 Different phage display libraries.^1,4

Our phage display platform identifies high-affinity peptides and antibodies through combinatorial library screening. Using bacteriophage-expressed protein libraries, we isolate binders with exceptional specificity to your target antigen. This approach enables rapid monoclonal antibody generation and novel peptide discovery, leveraging our optimized screening protocols to deliver validated candidates with minimal project timelines.

Yeast Display Platform

Express Proteins with Efficiency and Flexibility

Utilize yeast's eukaryotic expression advantages for antibody discovery and protein interaction studies. Our platform displays recombinant proteins on yeast surfaces, enabling direct screening of functional molecules. The system supports high-throughput analysis of thousands of candidates while maintaining native protein folding—ideal for developing therapeutic leads with confirmed biological activity.

The Schematic of yeast display. (Creative Biolabs Original)

Hybridoma Platform

Gold Standard in Monoclonal Antibody Development

Hybridoma technology remains a cornerstone of monoclonal antibody development due to its:

Proven Reliability – Stable cell lines with long-term productivity
Isotype Versatility – Ideal for generating IgG, IgA, and more
Clone Stability – Reproducible results for scale-up and downstream engineering
Species Flexibility – Broad compatibility beyond mice: rat, rabbit, and even camelid fusions

We pioneer advanced hybridoma technologies to redefine monoclonal antibody development. With decades of support for pharmaceutical, biotech, and academic partners, our robust platform integrates classical methods with modern innovations. By fusing immune cells with myeloma cells, we generate stable hybridomas producing specific, high-yield research antibodies.

Hyperdoma™ Platform

Fast & Scalable & Reliable

Need several monoclonals screened in record time? Our Hyperdoma™ platform is made for you. This platform enables rapidly screen several monoclonals using optimized immunization, efficient electrofusion, and advanced ELISA/flow-based screening—all in one streamlined workflow.

Hyperdoma™ Platform. (Creative Biolabs Authorized)

Omni-Hybridoma™ Technology

One Platform, Unlimited Possibilities

Omni-Hybridoma™ integrates next-generation immunization techniques, multi-species fusion options, and custom screening workflows, offering maximum design flexibility and target specificity. This platform adapts to complex needs like humanized models, difficult antigens, or subclass-specific antibodies through next-gen immunization and custom screening.

Omni-Hybridoma™ Technology. (Creative Biolabs Authorized)

Magic Hybridoma™ Technology

Challenging Targets Require Magical Solutions

Magic Hybridoma™ is purpose-built for difficult antigens, including low-immunogenicity proteins, glycosylated antigens, and conformational epitopes. By fusing enhanced adjuvant systems (e.g., the novel Magic Mouse Adjuvant), proprietary screening matrices, and smart clone selection strategies, this platform can do what traditional hybridomas cannot. If your antibody project hit a wall elsewhere, Magic Hybridoma™ might be your way through it.

Magic Hybridoma™ Technology. (Creative Biolabs Authorized)

Single B Cell Sorting Platform

Isolate the Antibodies You Need, Fast and Accurately

Need to find rare B cells making your ideal antibodies? Our single B cell sorting platform does exactly that. Think of it as precision targeting – we'll help find, isolate, and analyze individual B cells producing that exact antibody you need. We sort single cells at high speed, screening thousands to spot the best potential antibody makers quickly. You get fresh, untouched antibodies straight from the top-performing cells. Why's this better than traditional routes? Simple: no need to wait months or deal with hybridoma hassles. Your team can actually discover top-tier antibodies faster because we combine smart cell sorting with next-gen sequencing. As for isolation, we offer multiple reliable approaches to grab those valuable B cells efficiently. Here are our technologies provided for single B cell isolation:

Fig.2 Single cell mAb cloning via FACS. (OA Literature). Fig.2 The workflow for FACS-based single cell mAb cloning.^2,4

Fluorescent Activated Cell Sorting (FACS) Technology

Enables high-speed sorting of rare B cell subsets
Ideal for isolating antigen-specific memory B cells
Offers superior sorting accuracy in complex mixtures
Adaptable for both small-scale and large-throughput studies
Compatible with fluorescent-tagged antigen probes

The workflow for LCM technology. (Creative Biolabs Original).

Laser-Capture Microdissection (LCM) Technology

Allows precise extraction of B cells from tissue architecture
Especially useful when spatial localization matters
No physical contact—reduces sample contamination risks
Perfectly suited for studying tumor-infiltrating B cell populations
Excellent for working with FFPE samples or biopsy-derived sections

Fig.3 The workflow of microengraving system used for antibody discovery. (OA Literature). Fig.3 Antibody discovery using microengraving system.^2,4

Microengraving Technology

Screens thousands of single B cells for secreted antibodies in parallel
No cell destruction—recovered clones remain viable for expansion
Well-suited for vaccine response monitoring and lead selection
Captures functional heterogeneity among isotype-switched B cells
An elegant solution when function matters more than phenotype

Fig.4 Illustration explaining the core principles and step-by-step workflow of microfluidic technology, showcasing key processes and components involved. (OA Literature). Fig.4 Fundamentals and process flow of microfluidic technology.^3,4

Droplet Microfluidic Technology

Encapsulates single B cells in picoliter droplets with remarkable precision
Facilitates on-chip pairing of BCR genes with secretion profiles
A go-to technology for massive-scale immune repertoire studies
Automation-friendly—ideal for industrial antibody pipeline acceleration
Provides real-time functional data with high statistical power

Membrane Protein Platform

Study the Essential Membrane Proteins & Antibodies

Membrane proteins are complex molecules that drive crucial biological processes like cell signaling and drug transport, but their hydrophobic nature makes them notoriously tricky to handle. Our membrane protein platform cuts through these challenges. We provide optimized expression systems that deliver functional proteins every time. Whether you're working with GPCRs, ion channels, or transporters, our team handles the tough parts of expression and purification so you get reliable results faster.

MPAT™ Multi-Spanner Antibody Technology

Stuck on multi-spanner membrane proteins? MPAT™ changes the game. This proprietary tech generates highly specific antibodies against these difficult targets—the kind that actually perform in research and drug discovery screens. No more settling for unstable reagents.

The Schematic of membrane protein (blue). (Creative Biolabs Authorized).

Multiple Epitopes Antigen Designer (MEAD™) Technology

Need smarter antigen design? MEAD™ is your solution. This platform lets you engineer multi-epitope antigens that boost immune responses significantly. Combine epitopes from single or multiple proteins to create precision tools for vaccines and targeted therapies. It's like giving your research a precision upgrade.

图片12：The Schematic of membrane protein (red). (Creative Biolabs Authorized).

Ready to know more about our MemDX™ membrane protein production in VLPs?

Get faster, more efficient solutions for antibody and protein research with Creative Biolabs' precision-driven platforms.

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Protein Engineering Platform

Customizing Proteins to Meet Your Exact Needs

At Creative Biolabs, we believe that protein engineering is the future of biotechnology. Our protein engineering platform is designed to help you optimize proteins for specific functions. Using cutting-edge techniques like site-directed mutagenesis, directed evolution, and structure-based design, we offer tailored solutions to enhance protein properties, including stability, activity, and specificity. From developing custom antibodies to engineering enzymes for specific substrates, our platform helps create proteins that perform exactly as you envision.

Hot Products

Antibody Library ID	Species	Display Technology	Library Format	Library Size
HuScL-6	Human	pIII-fusion, Phagemid Phage Display	Naïve scFv	2.1×10¹¹
HuScL-7	Human	pIII-fusion, Phagemid Phage Display	Naïve scFv	1.1×10¹⁰
HuScL-3S	Human	pIII-fusion, Phagemid Phage Display	Semi-synthetic scFv	>1.0×10¹¹
HuFabL-4	Human	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.9×10¹⁰
HuFabL-5	Human	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.1×10¹⁰
HuFabssL-1	Human	pIII-fusion, Phagemid Phage Display	Naïve & synthetic Fab	1.8×10¹⁰
HuscL-YDP-3	Human	Yeast Display	Naïve scFv	1.9×10⁸
MuScL-2	Mouse	pIII-fusion, Phagemid Phage Display	Naïve scFv	5.3×10¹⁰
MuFabL-2	Mouse	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.2×10¹⁰
RaFabL-1	Rabbit	pIII-fusion, Phagemid Phage Display	Naïve Fab	7.5×10⁹
RaFabL-2	Rabbit	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.2×10¹⁰
Chicken-ScL-2	Chicken	pIII-fusion, Phagemid Phage Display	Naïve scFv	1.1×10¹⁰
CaVHHL-4	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	2.63×10¹⁰
CaVHHL-5	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	3.0×10¹⁰
CaVHHL-6	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	2.43×10⁹
LlaVHHL-1	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	1.9×10¹⁰
LlaVHHL-2	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	1.8×10¹⁰
AlVHHL-1	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	1.35×10¹⁰
AlVHHL-2	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Naïve VHH	1.5×10¹¹
LlaVHHL-S1	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Synthetic VHH	1.5×10¹¹
CaVHHL-S2	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Synthetic VHH	5.4×10¹⁰
CaVHHL-S3	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Synthetic VHH	2.2×10¹⁰
CaVHHL-S4	VHH (Camel, Llama, Alpaca)	pIII-fusion, Phagemid Phage Display	Semi-synthetic VHH	5.3×10¹⁰
LlaVHH-YPD-1	VHH (Camel, Llama, Alpaca)	Yeast Display	Naïve VHH	2×10⁸
HuVHHL-S1	Humanized VHH	pIII-fusion, Phagemid Phage Display	Synthetic VHH	>1.0×10¹¹
HuVHHL-S2	Humanized VHH	pIII-fusion, Phagemid Phage Display	Semi-synthetic VHH	>1.0×10¹⁰

References

Zhang, Tiantian, and Zhe Wang. "Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform." Biologics 4.1 (2024): 55-74. https://doi.org/10.3390/biologics4010005
Song, Qing. "Microsystem enabled single cell monoclonal antibody cloning for antibody immunotherapy of HIV infection." Global Vaccines and Immunology 2016, Volume 1(2): 24-28. https://www.nature.com/articles/srep27223
Beneyton, Thomas, et al. "High-throughput screening of filamentous fungi using nanoliter-range droplet-based microfluidics." Scientific reports 6.1 (2016): 27223. https://www.sci-hub.ru/10.1038/srep27223
Distributed under Open Access license CC BY 4.0, without modification.