Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsFull-length membrane proteins are important targets in antibody discovery and drug development. However, their hydrophobic transmembrane regions and dependence on the surrounding lipid environment make them difficult to express, isolate, and maintain in a native conformation. MNPs provide a convenient, cell-free alternative to whole-cell antigens and are particularly suitable for challenging multi-pass membrane proteins, including GPCRs, ion channels, transporters, tetraspanins, and Claudin-family proteins.
Our MNP full-length membrane protein products are presented in membrane nanoparticles derived from mammalian cells expressing the target protein. The target remains embedded in a native-like phospholipid bilayer, helping preserve its full-length structure, membrane orientation, extracellular conformational epitopes, and mammalian post-translational modifications.
MNP products are target-enriched membrane particle preparations rather than target proteins purified to homogeneity. Matched control MNPs are therefore recommended for background subtraction and specificity assessment.
Fig 1. Schematic illustration of full-length membrane protein presentation in membrane nanoparticles (MNPs).
Our MNP products combine mammalian expression with cell membrane-derived nanoparticle technology to provide full-length membrane proteins in a native-like lipid environment. This format offers a convenient and reliable antigen source for research on complex membrane targets.
Retains the complete membrane protein and key conformational epitopes within a cell-derived lipid bilayer.
Supports proper membrane insertion, folding, glycosylation, and other relevant post-translational modifications.
Provides concentrated membrane-protein presentation without the need to culture or maintain target-expressing cells.
Supports diverse targets, species, isoforms, tags, and scales, with target-specific identity and binding validation.
Creative biolabs offers a broad portfolio of MNP full-length membrane protein products that preserve target proteins in a native-like mammalian membrane environment. These ready-to-use reagents support research on challenging membrane targets and help accelerate antibody discovery, binding characterization, and assay development.
Serve as full-length antigens for hybridoma development, single B-cell screening, and other antibody discovery workflows requiring conformational epitopes.
Support antibody screening and phage, yeast, or mammalian display selection. Matched control MNPs can be used for negative selection and specificity assessment.
Enable antibody–antigen and ligand–receptor binding studies using ELISA, flow-based analysis, SPR, BLI, and other compatible assays.
Support target-binding evaluation of CARs, TCRs, and engineered receptors, as well as assay optimization, reagent qualification, and candidate comparison.
We offer a growing portfolio of full-length membrane protein products presented in membrane nanoparticles (MNPs). Supported by our experience in mammalian protein expression and membrane nanoparticle preparation, these products provide reliable, native-like antigens for membrane protein research and drug discovery. Browse the product list below or contact us for product selection and custom development support.
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.
