Voltage-gated Potassium Channel Beta Subunit Family

Voltage-gated potassium channels (VGKCs) are identified as transmembrane channels that are specific for potassium and sensitive to voltage changes in the cell's membrane potential and play a key role in setting the resting membrane potential. VGKCs are assembled from membrane-integrated alpha subunits and auxiliary beta subunits and are involved in a variety of functions, including secretion, electrogenesis, and cell motility. Voltage-gated potassium channel beta subunits are cytoplasmic proteins that co-purify with the pore-forming alpha subunits. Beta subunits are auxiliary proteins which associate with alpha subunits, sometimes in an alpha4beta4 stoichiometry. The potassium channel beta subunits are found in particular abundance in the central nervous system of mammals, and also expressed in invertebrates and plants.

Voltage-gated potassium channel beta subunits do not conduct current on their own but rather regulate the activity of Kv (potassium voltage-gated ion) channels. And they are suggested to be functionally important in human heart. Here, the two members of voltage-gated potassium channel beta subunit family are covered in further detail.

Human Voltage-gated Potassium Channel Beta Subunit Members

Based on our Magic™ membrane protein production platform, scientists at Creative Biolabs have devoted themselves in providing the protein preparation services of these membrane proteins mentioned above in required formats through different strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

In addition, Magic™ membrane protein antibody discovery platform at Creative Biolabs can be utilized for developing antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for technical help.

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