3D Ex Vivo Human Adrenoceptors-Isoprenaline (Healthy) Model Introduction

At Creative Biolabs, we are committed to providing scientific workers with the best 3D ex vivo human adrenoceptors-isoprenaline model to advance their projects.

Adrenoceptors and Isoprenaline

Beta-adrenoceptors are a subtype of adrenoceptors that respond to the neurotransmitters norepinephrine and epinephrine. Isoprenaline is a synthetic compound that activates beta-adrenoceptors, leading to a variety of physiological responses such as increased heart rate and dilation of the bronchi. Research on beta-adrenoceptors and isoprenaline has focused on their role in cardiovascular diseases such as hypertension and heart failure, as well as respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

Isoprenaline can change the state of blood vessels and heart rate. Fig 1. Isoprenaline affects the heart rate and blood pressure.¹

Despite significant research on the physiological effects of beta-adrenoceptors and isoprenaline, there is still a lack of understanding of the pathogenic mechanisms underlying diseases related to this pathway. Further research is needed to elucidate the complex interactions between beta-adrenoceptors, isoprenaline, other physiological pathways and the precise mechanisms by which they exert their therapeutic effects.

Traditional Adrenoceptors-Isoprenaline Model

Isoprenaline induces cardiac hypertrophy.(Li, 2023)

Traditional research models for studying beta-adrenoceptors and related diseases include in vitro cell culture systems and in vivo animal models. However, these models have severe limitations. In vitro cell culture systems may not accurately reflect the complexity of human physiology, and animal models may not fully recapitulate human disease. In addition, ethical concerns and differences in drug metabolism between humans and animals can limit the applicability of animal models in drug development.

Human Ex Vivo Adrenoceptors-Isoprenaline Model

Better representation o f human physiology and architecture;
Increased accuracy and reproducibility of experimental results;

Potential reduction in the need for animal models;
Facilitation of drug discovery and development.

Our Services

As a leading supplier of the human tissue sample, Creative Biolabs provides researchers with an outstanding and comprehensive 3D ex vivo human beta-adrenoceptor-isoprenaline model, which serves as a valuable tool for studying beta-adrenoceptor signaling and related diseases. Our team of seasoned experts provides guidance and professional support throughout the research process, including experimental design and data analysis. We are committed to maintaining strict confidentiality and security for each sample, which is supported by comprehensive clinical information and relevant data.

You are always welcome to choose our secondary airways (healthy) contractility model to promote your research.

With our expertise in tissue processing and modeling, combined with our procurement and supply network, Creative Biolabs is the ideal partner for researchers seeking to advance their understanding of beta-adrenoceptor-isoprenaline system diseases. Contact us today to discuss your research needs and discover how we can provide you with the best possible solutions and resources to achieve your research goals.

References

Dewenter, Matthias et al. "Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses." Basic research in cardiology. 117,1 (2022): 15. 14 Mar. Distributed under Open Access license CC BY 4.0, the original image's title was changed to "Isoprenaline affects the heart rate and blood pressure".
Li, Yu et al. "Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway." Nutrients. 15,6 (2023): 1340. Distributed under Open Access license CC BY 4.0, without modification.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

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