Tumor Organoid and PBMC Co-Culture Model for Immuno-Oncology Drug Discovery and Development

Cancer has perpetually stood as the esteemed focal point of medical and immunological research. Creative Biolabs takes great pride in introducing the tumor organoid and peripheral blood mononuclear cells (PBMCs) co-culture model, devised to propel the frontiers of immuno-oncology research and facilitate the realization of profoundly efficacious interventions in cancer.

PBMCs and Tumor Organoid

The majority of studies regarding tumor immune evasion mechanisms have primarily centered around the T cell immune response against tumor tissues, encompassing the distinct tumor microenvironment and peripheral blood environment. The co-cultivation of PBMCs with tumor organoids has emerged as a critical objective in the establishment of in vitro models for investigating the interactions between the tumor and immune system, as well as for evaluating immunotherapeutic approaches.

Why Choose Creative Biolabs?

Composed of lymphocytes, monocytes, and natural killer cells, the co-culture model involving tumor organoids and PBMCs has emerged as an indispensable tool for studying the intricate interactions between tumors and the immune system. Our tumor organoid and PBMCs co-culture model takes the immuno-oncology research and exploration of immunotherapeutic agents a step further.

• By co-culturing tumor organoids with PBMCs, we recreate in vitro conditions that closely resemble the tumor microenvironment, allowing for a more accurate assessment of drug response and immune cell behavior.
• By isolating PBMCs from peripheral blood samples, Creative Biolabs’ co-culture models allow researchers to gain access to an expanse of immune cells derived from the patient's system.
• Our model empowers scientific workers to scrutinize, evaluate, and analyze key parameters such as immune cell activation, cytokine release kinetics, and the ensuing cascade of tumor stimulation.

Applications

High-throughput Screening

Compared to the laborious and challenging xenograft and animal models, the organoid co-culture system offers a more accessible platform, facilitates streamlined experimental procedures and efficient data acquisition.

Heterogeneity Evaluation

By co-culturing tumor cells and PBMCs, our model provides a physical environment to investigate intricate cellular interactions and generate tumor-specific T cells, enabling the study of complex relationships between different cell types.

Personalized Medicine

The tumor organoid co-culture model allows the construction of models using primary tumor cells and PBMCs directly obtained from individual patients, contributing to the progress of personalized medical approaches tailored to the unique characteristics of each patient.

Immunology Research

The co-culture tumor organoids provide a powerful tool for studying cancer-T cell interactions and deciphering the determinants of reactivity, and serve as a comprehensive platform for in-depth investigations and analyses.

What We Provide?

Creative Biolabs proudly offers comprehensive services utilizing the tumor organoid and PBMCs co-culture model for immuno-oncology drug discovery. The tumor organoid co-culture model allows high-throughput screening and organ-based analysis strategies, facilitating preclinical evaluation and guiding treatment decisions. This cutting-edge toolset enhances our capabilities in the field of oncology research. Please feel free to reach out to us for consultations or to discuss specific requirements.

Related Sections:

• Tumor Organoid Monoculture Model for Immuno-Oncology Drug Discovery and Development
• Tumor Organoid and Immune Cell Co-culture Model for Immuno-Oncology Drug Discovery and Development