Acetylcholine Receptor Family

Acetylcholine receptor (AChR), also named cholinergic receptor, is a membrane protein that responds to the binding of a neurotransmitter, acetylcholine. It consists of a pentamer (subunit composition) and presents in the cluster on muscle-cell membranes opposite the active zone of presynaptic terminals. This receptor is an ion channel spanning the membrane and contains an extracellular, transmembrane and cytoplasmic domain, the latter part being the most variable. The density of AChR at the receptor region is between 7,000-30,000 sites per square micrometer. It is located basically over the peaks of postsynaptic folds and appears at a high density.

Acetylcholine receptors (AChRs) are divided into two subtypes that bind acetylcholine and transmit their signals, muscarinic (mAChR) and nicotinic (nAChR), named after agonist activities of natural alkaloids, muscarine and nicotine, respectively. These receptors are different in function. The mAChR being G-protein coupled receptors (GPCRs) mediates a slow metabolic response through second messenger cascades, while the nAChR is ligand-gated ion channel, mediating a fast synaptic transmission of the neurotransmitter. Skeletal muscles are sufficient with the nAChR and are devoid of the mAChR. Here shows part of AChRs in humans in this table.

Human AChR Family Members

Assisted with world-class Magic™ membrane protein production platform, Creative Biolabs is willing to provide the preparation of these proteins in required formats via various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Here, our versatile Magic™ membrane protein antibody discovery platform can help to find antibodies against these targets, even fully humanized antibodies, using quantities of techniques such as hybridoma technology, phage display technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.

Online Inquiry

Verification code
Click image to refresh the verification code.


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
Europe: Heidenkampsweg 58, 20097 Hamburg, Germany
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us