Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAcetylcholine receptor (AChR), also named cholinergic receptor, is a membrane protein that responds to the binding of a neurotransmitter, acetylcholine. It consists of a pentamer (subunit composition) and presents in the cluster on muscle-cell membranes opposite the active zone of presynaptic terminals. This receptor is an ion channel spanning the membrane and contains an extracellular, transmembrane and cytoplasmic domain, the latter part being the most variable. The density of AChR at the receptor region is between 7,000-30,000 sites per square micrometer. It is located basically over the peaks of postsynaptic folds and appears at a high density.
Acetylcholine receptors (AChRs) are divided into two subtypes that bind acetylcholine and transmit their signals, muscarinic (mAChR) and nicotinic (nAChR), named after agonist activities of natural alkaloids, muscarine and nicotine, respectively. These receptors are different in function. The mAChR being G-protein coupled receptors (GPCRs) mediates a slow metabolic response through second messenger cascades, while the nAChR is ligand-gated ion channel, mediating a fast synaptic transmission of the neurotransmitter. Skeletal muscles are sufficient with the nAChR and are devoid of the mAChR. Here shows part of AChRs in humans in this table.
Assisted with world-class MemDX™ membrane protein production platform, Creative Biolabs is willing to provide the preparation of these proteins in required formats via various strategies, including detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Here, our versatile MemDX™ membrane protein antibody discovery platform can help to find antibodies against these targets, even fully humanized antibodies, using quantities of techniques such as hybridoma technology, phage display technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
