CHRNB1 Membrane Protein Introduction

Introduction of CHRNB1

The full name of CHRNB1 is acetylcholine receptor subunit beta. The chemical transmission of electrical signals from the nervous system to skeletal muscle is mediated by the muscle nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction. nAChR consists of five homologous subunits. CHRNB1 is one of the subunits. The gene encoding the muscle receptor beta subunit, CHRNB1, is located on the short arm of chromosome 17. CHRNB1 and CHRND produce proteins with close homology to the α1 subunit, but without two adjacent cysteines in the N-terminal domain.

Basic Information of CHRNB1
Protein Name	Acetylcholine receptor subunit beta
Gene Name	CHRNB1, ACHRB, CHRNB
Aliases	/
Organism	Homo sapiens (Human)
UniProt ID	P11230
Transmembrane Times	4
Length (aa)	501
Sequence	MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYHLPPPDPFP

Function of CHRNB1 Membrane Protein

As one of the subunits of the nicotinic acetylcholine receptor, CHRNB1 is involved in the regulation of ion channel activity, thereby affecting the contractility of skeletal muscle. The expression levels in the nervous system, adrenal gland, thyroid gland and placenta are relatively high in healthy human. It has also been found to play a role in diseases such as myasthenia gravis, Alzheimer's disease, autism spectrum disorders and Down syndrome.

CHRNB1 Membrane Protein Introduction Fig.1 Computer simulation of CHRNB1 protein.

Application of CHRNB1 Membrane Protein in Literature

Aishah A., et al. Cellular protein and mRNA expression of β1 nicotinic acetylcholine receptor (nAChR) subunit in brain, skeletal muscle and placenta. Int J Dev Neurosci. 2017, 58:9-16. PubMed ID: 28153524

This study reported the presence of CHRNB1 at the cellular level in human skeletal muscle and placenta, and mRNA expression reflected protein expression in cell types.
Vogt J., et al. Mutation analysis of CHRNA1, CHRNB1, CHRND, and RAPSN genes in multiple pterygium syndrome/fetal akinesia patients. Am J Hum Genet. 2008, 82(1):222-7. PubMed ID: 18179903

This article reported that no CHRNB1 mutation was detected in 15 fatal multiple pterygium syndromes (MPS).
Carlisle D.L., et al. Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulm Pharmacol Ther. 2007, 20(6):629-41. PubMed ID: 17015027

The β1 subunit exhibited significantly increased expression in lung tumors compared to non-tumor bronchial tissue.
Lou X.Y., et al. Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. Hum Genet. 2006, 120(3):381-9. PubMed ID: 6874522

This paper showed that CHRNB1 was associated with the susceptibility to nicotine dependence.
Gomez C.M., et al. A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome. Ann Neurol. 1996, 39(6):712-23. PubMed ID: 8651643

It has been reported that spontaneous mutation of the beta subunit in the acetylcholine receptor channel gate interrupted the leucine loop of the AChR channel gate resulting in an eight-fold increase in channel open time, and severe slow-channel congenital myasthenic syndromes (CMS) characterized by severe endplate myopathy and extensive remodeling of the postsynaptic membrane.

CHRNB1 Preparation Options

Membrane protein studies have advanced significantly over the past few years. Based on our versatile Magic™ membrane protein production platform, we could offer a series of membrane protein preparation services for worldwide customers in reconstitution forms or membrane protein mutants. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CHRNB1 antibody development services.

During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. We are happy to accelerate the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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