This product is a GA-10 (Clone 4) B cell engineering tool based on the Solid lipid nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-321-crispr RNA-SpCas9-SCR7 pyrazine) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | EZR |
| Insert Clone | B6CR244 |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-2 |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-50 |
| Charge (mv) | -18 to -84 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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