This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (N-acetyl-D-glucosamine,sialic acid/Wheat germagglutinin) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas12-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEUROG2 |
| Insert Clone | 15H30L21CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | L755507 |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | ≤900 |
| Charge (mv) | 6 to 86 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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