This product is a Pfeiffer B cell engineering tool based on the Gold nanoparticles (Anisamide/ Sigma receptors) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-Brefeldin A) genome editor.
| Host Cell | Pfeiffer |
| Target | NEUROG2 |
| Insert Clone | 7G4CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Anisamide/ Sigma receptors |
| Active Agents | DOX |
| Particle Size | 20-150 |
| Charge (mv) | -5 to -40 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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