This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-SCR7 pyrazine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEUROG2 |
| Insert Clone | BCGW-1345CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Thymoquinone |
| Particle Size | 10-500 |
| Charge (mv) | <80 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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