This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEUROG3 |
| Insert Clone | GF1CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Thymoquinone |
| Particle Size | 10-50 |
| Charge (mv) | -18 to -84 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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