4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid (TDBA) Photo-reactive Crosslinker (CAT#: OLY-1023-YS33)
Datasheet MSDSCas No.: 85559-46-2
PRODUCT INFORMATION
Description
TDBA is a heterobifunctional, photo-reactive crosslinker used for photoaffinity labeling (PAL). It possesses a carboxylic acid group, which can be activated (e.g., with EDC/NHS) to couple with primary amines on a 'bait' molecule. The other end features a trifluoromethyl-diazirine group. This moiety is stable in the dark but, upon activation with UV light (approx. 350-370 nm), generates a highly reactive carbene. This carbene non-selectively inserts into nearby C-H, N-H, or O-H bonds of an interacting 'prey' protein, permanently capturing transient interactions and enabling target identification.
Molecular Weight
230.15
Purity
>98.0%
Formula
C₉H₅F₃N₂O₂
Product Type
Heterobifunctional Crosslinkers ; Photo-reactive Crosslinkers
Group 1
CHO
Group 2
X (F, Cl, Br, I)
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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