4-Maleimidobutyric Acid Heterobifunctional Crosslinker (CAT#: OLY-1023-YS10)

Description

This is a non-cleavable, heterobifunctional crosslinker featuring a sulfhydryl-reactive maleimide group and a terminal carboxylic acid, separated by a short 4-carbon (C4) aliphatic spacer. The maleimide group reacts specifically with thiols (cysteine residues) at pH 6.5-7.5. The carboxylic acid can be activated (e.g., with EDC/NHS) to react with primary amines (lysine residues). This linker is used to covalently connect amine-containing molecules to thiol-containing molecules over a short, defined distance, making it useful for creating stable bioconjugates or for surface functionalization.

Molecular Weight

183.16

Purity

>98.0%

Formula

C₈H₉NO₄

Product Type

Heterobifunctional Crosslinkers

Group 1

Maleimide

Group 2

COOH

Form (20 deg.C)

Solid

Storage Condition

2-8°C

Molecular Structure