Cas No.: 159857-81-5
PRODUCT INFORMATION
Description
This is a gold-standard, protease-cleavable linker payload for Antibody-Drug Conjugates (ADCs). It contains: 1) A maleimide-caproyl (Mc) group to conjugate to antibody thiols. 2) A Valine-Citrulline (Val-Cit) dipeptide, which is a substrate for lysosomal proteases (e.g., Cathepsin B). 3) A PABC (p-aminobenzyloxycarbonyl) self-immolative spacer. 4) A p-nitrophenyl (PNP) active ester for attaching the drug. Once the ADC is internalized and the Val-Cit linker is cleaved in the lysosome, the PABC spacer fragments, releasing the active drug.
Molecular Weight
737.77
Purity
>97.0%
Formula
C₃₅H₄₃N₇O₁₁
Product Type
Enzyme Cleavable Linkers for ADC Preparation
Group 1
Maleimide
Group 2
Other
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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