1,4-Bis(maleimido)butane Homobifunctional Crosslinker (CAT#: OLY-1023-YS124)

Description

This is a homobifunctional, sulfhydryl-reactive crosslinker. It consists of two maleimide groups separated by a short, 4-carbon (C4) aliphatic spacer. Maleimide groups react specifically with thiols (cysteines) at neutral pH (6.5-7.5) to form stable, non-cleavable thioether bonds. BMB is primarily used to crosslink two different thiol-containing molecules (e.g., two peptides) or to induce intramolecular crosslinks between two cysteine residues within the same protein. This can be used to study or stabilize protein tertiary/quaternary structure.

Molecular Weight

248.24

Purity

>98.0%

Formula

C₁₂H₁₂N₂O₄

Product Type

Homobifunctional Crosslinkers

Group 1

Maleimide

Group 2

Maleimide

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, <0°C

Molecular Structure