SDPD-PEG4-NHS PEGylation Crosslinker (CAT#: OLY-1023-YS19)

Description

This is a heterobifunctional, reducible PEGylation crosslinker. It contains an amine-reactive NHS ester and a thiol-reactive pyridyldithiol (SPDP) group, connected by a 4-unit PEG spacer. The NHS ester reacts with amines. The SPDP group reacts with thiols to form a disulfide bond. This bond is readily cleaved by reducing agents (e.g., DTT, or intracellular glutathione). This cleavability is essential for its use in drug delivery, particularly as a linker for Antibody-Drug Conjugates (ADCs), where release of the drug payload inside the target cell is required. The PEG4 spacer adds hydrophilicity.

Molecular Weight

559.65

Purity

>98.0%

Formula

C₂₃H₃₃N₃O₉S₂

Product Type

Heterobifunctional Crosslinkers ; PEGylation Reagents

Group 1

Other

Group 2

NHS

Form (20 deg.C)

Liquid

Storage Condition

Store under inert gas, <0°C

Molecular Structure