Cas No.: 1334177-95-5
PRODUCT INFORMATION
Description
This is a heterobifunctional, reducible PEGylation crosslinker. It contains an amine-reactive NHS ester and a thiol-reactive pyridyldithiol (SPDP) group, connected by a 4-unit PEG spacer. The NHS ester reacts with amines. The SPDP group reacts with thiols to form a disulfide bond. This bond is readily cleaved by reducing agents (e.g., DTT, or intracellular glutathione). This cleavability is essential for its use in drug delivery, particularly as a linker for Antibody-Drug Conjugates (ADCs), where release of the drug payload inside the target cell is required. The PEG4 spacer adds hydrophilicity.
Molecular Weight
559.65
Purity
>98.0%
Formula
C₂₃H₃₃N₃O₉S₂
Product Type
Heterobifunctional Crosslinkers ; PEGylation Reagents
Group 1
Other
Group 2
NHS
Form (20 deg.C)
Liquid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- [4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl]methanamine Hydrochloride Heterobifunctional Crosslinker (CAT#: OLY-1023-YS82)
- 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (CAT#: OLY-1023-YS284)
- Di(N-succinimidyl) Pimelate Homobifunctional Crosslinker (CAT#: OLY-1023-YS136)
- N-([ε-Maleimidocaproyloxy)sulfosuccinimide Ester (Sulfo-EMCS) (CAT#: OLY-1023-YS88)
- N,N'-Disuccinimidyl Carbonate (CAT#: OLY-1023-YS131)
- m-PEG4-lipoamide (CAT#: OLY-1023-YS250)
- m-PEG2-bromide PEGylation Crosslinker (CAT#: OLY-1023-YS247)
- N-Succinimidyl Methacrylate Heterobifunctional Crosslinker (CAT#: OLY-1023-YS25)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.