Cas No.: 1334177-95-5
PRODUCT INFORMATION
Description
This is a heterobifunctional, reducible PEGylation crosslinker. It contains an amine-reactive NHS ester and a thiol-reactive pyridyldithiol (SPDP) group, connected by a 4-unit PEG spacer. The NHS ester reacts with amines. The SPDP group reacts with thiols to form a disulfide bond. This bond is readily cleaved by reducing agents (e.g., DTT, or intracellular glutathione). This cleavability is essential for its use in drug delivery, particularly as a linker for Antibody-Drug Conjugates (ADCs), where release of the drug payload inside the target cell is required. The PEG4 spacer adds hydrophilicity.
Molecular Weight
559.65
Purity
>98.0%
Formula
C₂₃H₃₃N₃O₉S₂
Product Type
Heterobifunctional Crosslinkers ; PEGylation Reagents
Group 1
Other
Group 2
NHS
Form (20 deg.C)
Liquid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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