Cas No.: 1334177-95-5
PRODUCT INFORMATION
Description
This is a heterobifunctional, reducible PEGylation crosslinker. It contains an amine-reactive NHS ester and a thiol-reactive pyridyldithiol (SPDP) group, connected by a 4-unit PEG spacer. The NHS ester reacts with amines. The SPDP group reacts with thiols to form a disulfide bond. This bond is readily cleaved by reducing agents (e.g., DTT, or intracellular glutathione). This cleavability is essential for its use in drug delivery, particularly as a linker for Antibody-Drug Conjugates (ADCs), where release of the drug payload inside the target cell is required. The PEG4 spacer adds hydrophilicity.
Molecular Weight
559.65
Purity
>98.0%
Formula
C₂₃H₃₃N₃O₉S₂
Product Type
Heterobifunctional Crosslinkers ; PEGylation Reagents
Group 1
Other
Group 2
NHS
Form (20 deg.C)
Liquid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- N-Succinimidyl 4-Benzoylbenzoate Photo-reactive Crosslinker (CAT#: OLY-1023-YS30)
- Mal-NH-PEG4-OtBu PEGylation Crosslinker (CAT#: OLY-1023-YS18)
- N-Succinimidyl 4-(4-Maleimidophenyl)butyrate (SMPB) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS53)
- 6-Maleimido-hexanoic NHS (EMCS) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS109)
- Acetylthio-PEG4-alkyne Heterobifunctional Crosslinker (CAT#: OLY-1023-YS35)
- Alloc-Val-Cit-PAB-OH Enzyme Cleavable Linker for ADC (CAT#: OLY-1023-YS271)
- N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (SMCC) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS29)
- N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine (CAT#: OLY-1023-YS145)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.