Cas No.: 115597-84-7
PRODUCT INFORMATION
Description
This is a homobifunctional, sulfhydryl-reactive PEGylation crosslinker. It features two maleimide groups separated by a hydrophilic 2-unit polyethylene glycol (PEG) spacer. The maleimide groups react specifically with thiols (cysteines) at pH 6.5-7.5 to form stable thioether bonds. This linker is used to covalently crosslink two thiol-containing molecules. Compared to purely aliphatic linkers like 1,4-Bis(maleimido)butane, the PEG2 spacer increases the hydrophilicity of the linker and the final conjugate, which can reduce aggregation and improve aqueous solubility.
Molecular Weight
308.29
Purity
>98.0%
Formula
C₁₄H₁₆N₂O₆
Product Type
Homobifunctional Crosslinkers ; PEGylation Reagents
Group 1
Maleimide
Group 2
Maleimide
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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