Mal-PEG2-CH2CH2Mal PEGylation Crosslinker (CAT#: OLY-1023-YS125)

Description

This is a homobifunctional, sulfhydryl-reactive PEGylation crosslinker. It features two maleimide groups separated by a hydrophilic 2-unit polyethylene glycol (PEG) spacer. The maleimide groups react specifically with thiols (cysteines) at pH 6.5-7.5 to form stable thioether bonds. This linker is used to covalently crosslink two thiol-containing molecules. Compared to purely aliphatic linkers like 1,4-Bis(maleimido)butane, the PEG2 spacer increases the hydrophilicity of the linker and the final conjugate, which can reduce aggregation and improve aqueous solubility.

Molecular Weight

308.29

Purity

>98.0%

Formula

C₁₄H₁₆N₂O₆

Product Type

Homobifunctional Crosslinkers ; PEGylation Reagents

Group 1

Maleimide

Group 2

Maleimide

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, -20°C

Molecular Structure