Cas No.: 756525-99-2
PRODUCT INFORMATION
Description
This is a classic heterobifunctional, hydrophilic crosslinker. It features a sulfhydryl-reactive maleimide group (targets cysteines at pH 6.5-7.5) and an amine-reactive N-hydroxysuccinimide (NHS) ester (targets lysines at pH 7.0-9.0). The two are separated by a 4-unit polyethylene glycol (PEG) spacer. The PEG4 chain enhances aqueous solubility, reduces aggregation, and provides a flexible, 21.7 Å spacer arm. It is a staple reagent for conjugating antibodies to enzymes, peptides to proteins, or for creating Antibody-Drug Conjugates (ADCs).
Molecular Weight
513.50
Purity
>98.0%
Formula
C₂₂H₃₁N₃O₁₁
Product Type
PEGylation Reagents
Group 1
Maleimide
Group 2
NHS
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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