Cas No.: 756525-99-2
PRODUCT INFORMATION
Description
This is a classic heterobifunctional, hydrophilic crosslinker. It features a sulfhydryl-reactive maleimide group (targets cysteines at pH 6.5-7.5) and an amine-reactive N-hydroxysuccinimide (NHS) ester (targets lysines at pH 7.0-9.0). The two are separated by a 4-unit polyethylene glycol (PEG) spacer. The PEG4 chain enhances aqueous solubility, reduces aggregation, and provides a flexible, 21.7 Å spacer arm. It is a staple reagent for conjugating antibodies to enzymes, peptides to proteins, or for creating Antibody-Drug Conjugates (ADCs).
Molecular Weight
513.50
Purity
>98.0%
Formula
C₂₂H₃₁N₃O₁₁
Product Type
PEGylation Reagents
Group 1
Maleimide
Group 2
NHS
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- Bis-PEG5-NHS Ester PEGylation Crosslinker (CAT#: OLY-1023-YS167)
- 6-Biotinamidohexanoic Acid (CAT#: OLY-1023-YS190)
- Azido-PEG4-NHS Ester (CAT#: OLY-1023-YS100)
- Biotin-PEG2-maleimide (CAT#: OLY-1023-YS209)
- Amino-PEG6-acid PEGylation Crosslinker (CAT#: OLY-1023-YS63)
- β-Alanine tert-butyl Ester Hydrochloride Heterobifunctional Crosslinker (CAT#: OLY-1023-YS112)
- CPO-PFP Selective N-Terminal Cysteine Residue Crosslinker (CAT#: OLY-1023-YS4)
- N,N'-Disuccinimidyl Carbonate (CAT#: OLY-1023-YS131)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.