N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (SMCC) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS29)
Datasheet MSDSCas No.: 64987-85-5
PRODUCT INFORMATION
Description
SMCC is a non-cleavable, heterobifunctional crosslinker widely used for creating stable Antibody-Drug Conjugates (ADCs). It contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive maleimide group. The two are separated by a rigid cyclohexyl spacer, which provides defined spacing and enhances *in vivo* stability. The NHS ester reacts with amines (lysines) on the antibody, and the maleimide reacts with thiols (cysteines) on the drug payload, creating a highly stable, non-cleavable thioether linkage.
Molecular Weight
334.33
Purity
>98.0%
Formula
C₁₆H₁₈N₂O₆
Product Type
Heterobifunctional Crosslinkers
Group 1
NHS
Group 2
Maleimide
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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