N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (SMCC) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS29)
Datasheet MSDSCas No.: 64987-85-5
PRODUCT INFORMATION
Description
SMCC is a non-cleavable, heterobifunctional crosslinker widely used for creating stable Antibody-Drug Conjugates (ADCs). It contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive maleimide group. The two are separated by a rigid cyclohexyl spacer, which provides defined spacing and enhances *in vivo* stability. The NHS ester reacts with amines (lysines) on the antibody, and the maleimide reacts with thiols (cysteines) on the drug payload, creating a highly stable, non-cleavable thioether linkage.
Molecular Weight
334.33
Purity
>98.0%
Formula
C₁₆H₁₈N₂O₆
Product Type
Heterobifunctional Crosslinkers
Group 1
NHS
Group 2
Maleimide
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- CPO-PFP Selective N-Terminal Cysteine Residue Crosslinker (CAT#: OLY-1023-YS4)
- 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Bromide Photo-reactive Crosslinker (CAT#: OLY-1023-YS87)
- Acetylthio-PEG4-alkyne Heterobifunctional Crosslinker (CAT#: OLY-1023-YS35)
- Amino-PEG6-acid PEGylation Crosslinker (CAT#: OLY-1023-YS63)
- N-(2-Hydroxyethyl)maleimide Heterobifunctional Crosslinker (CAT#: OLY-1023-YS7)
- Mal-PEG3-CH2CH2Mal PEGylation Crosslinker (CAT#: OLY-1023-YS126)
- N-(2-Aminoethyl)maleimide Hydrochloride Heterobifunctional Crosslinker (CAT#: OLY-1023-YS90)
- 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride (CAT#: OLY-1023-YS292)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.