N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (SMCC) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS29)

Description

SMCC is a non-cleavable, heterobifunctional crosslinker widely used for creating stable Antibody-Drug Conjugates (ADCs). It contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive maleimide group. The two are separated by a rigid cyclohexyl spacer, which provides defined spacing and enhances *in vivo* stability. The NHS ester reacts with amines (lysines) on the antibody, and the maleimide reacts with thiols (cysteines) on the drug payload, creating a highly stable, non-cleavable thioether linkage.

Molecular Weight

334.33

Purity

>98.0%

Formula

C₁₆H₁₈N₂O₆

Product Type

Heterobifunctional Crosslinkers

Group 1

NHS

Group 2

Maleimide

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, <0°C

Molecular Structure