Home > Products > Ad Fiber Knob & ITGAV > Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody)

Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody)  (CAT#: SCDB-005)

Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
Datasheet INQUIRY

Specifications

Targets
Ad Fiber Knob & ITGAV
Type
Single-chain Diabody
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Prostate cancer; Ovarian cancer

Targets

Target 1
Ad Fiber Knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
ITGAV
Gene ID
UniProt ID
Alternative Names
ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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