Home > Products > B cell lymphoma BCL1 Idiotype & CD64 > Recombinant Anti-B cell lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-B cell lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-001)

Recombinant Anti-B cell lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-B cell lymphoma BCL1 Idiotype antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD64 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget immune cells to tumor cells. It is designed for the research of B cell lymphoma therapy.

Specifications
Targets
B cell lymphoma BCL1 Idiotype & CD64
Type
Fab-Fc Fusion Proteins
Species Reactivity
Mouse
Target 1
B cell lymphoma BCL1 Idiotype
Host Animal 1
Rat
Target 2
CD64
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma
Targets
Target 1
B cell lymphoma BCL1 Idiotype
Alternative Names
B cell lymphoma BCL1 Idiotype; B cell lymphoma; BCL1; Idiotype; Id; 31D1; 32D1
Target 2
CD64
Gene ID
UniProt ID
Alternative Names
FcγRI; FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); CD64; FCRI; CD64A; IGFR1; high affinity immunoglobulin gamma Fc receptor I; fcgammaRIa; Fc-gamma RI; fc-gamma RIA; Fc gamma receptor; IgG Fc receptor I; Fc-gamma receptor I A1; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCGR1B, FCGR1C
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