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B7H3 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0825-N39 Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc B7H3 Human 4-1BB Human Inquiry
KN-0825-N10 Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv B7H3 Human 4-1BB Human Inquiry
KN-1124-N1 Recombinant Mouse Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse B7H3 Human Inquiry
KN-0724-N1 Recombinant Human Anti-CD3 x Mouse Anti-B7H3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human B7H3 Mouse Inquiry
T-BSDB-H238 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human B7H3 Human Inquiry
T-BSDB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse B7H3 Mouse Inquiry
KN-0922-LN2 Recombinant Mouse Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse B7H3 Human Inquiry
SCIGG-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human B7H3 Human Inquiry
SCIGG-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse B7H3 Mouse Inquiry
FVTIG-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human B7H3 Human Inquiry
FVTIG-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse B7H3 Mouse Inquiry
BSSG-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human B7H3 Human Inquiry
BSSG-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse B7H3 Mouse Inquiry
IGLFV-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human B7H3 Human Inquiry
IGLFV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse B7H3 Mouse Inquiry
BSGV-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse B7H3 Mouse Inquiry
BSGV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse B7H3 Mouse Inquiry
BSDG-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human B7H3 Human Inquiry
BSDG-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse B7H3 Mouse Inquiry
BABFV-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human B7H3 Human Inquiry
BABFV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse B7H3 Mouse Inquiry
FABVC-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human B7H3 Human Inquiry
FABVC-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse B7H3 Mouse Inquiry
SCDBC-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human B7H3 Human Inquiry
SCDBC-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse B7H3 Mouse Inquiry
BSDBC-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human B7H3 Human Inquiry
BSDBC-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse B7H3 Mouse Inquiry
SCDBF-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human B7H3 Human Inquiry
SCDBF-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse B7H3 Mouse Inquiry
BSFVF-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human B7H3 Human Inquiry
BSFVF-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse B7H3 Mouse Inquiry
BSDBF-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human B7H3 Human Inquiry
BSDBF-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse B7H3 Mouse Inquiry
BSTF-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse B7H3 Mouse Inquiry
BSTF-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse B7H3 Mouse Inquiry
BSCFV-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse B7H3 Mouse Inquiry
BSCFV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse B7H3 Mouse Inquiry
MNAB-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse B7H3 Mouse Inquiry
MNAB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse B7H3 Mouse Inquiry
BSFC-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse B7H3 Mouse Inquiry
BSFC-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse B7H3 Mouse Inquiry
BSCC-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse B7H3 Mouse Inquiry
BSCC-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse B7H3 Mouse Inquiry
BIBD-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse B7H3 Mouse Inquiry
BIBD-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse B7H3 Mouse Inquiry
FABFV-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human B7H3 Human Inquiry
FABFV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse B7H3 Mouse Inquiry
MiniB-H240 Recombinant Human Anti-CD3 x Human Anti-B7H3 Bispecific Antibody (Minibody) Human Minibody CD3 Human B7H3 Human Inquiry
MiniB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse B7H3 Mouse Inquiry
SCTB-H134 Recombinant Human Anti-B7H3 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human B7H3 Human Inquiry
SCDB-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human B7H3 Human Inquiry
FABIG-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human B7H3 Human Inquiry
TRIB-H240 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human B7H3 Human Inquiry
BSIG-H238 Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human B7H3 Human Inquiry
CROSSAB-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human B7H3 Human Inquiry
IGFV-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human B7H3 Human Inquiry
BSDB-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (Diabody) Human Diabody CD3 Human B7H3 Human Inquiry
BSFAB-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human B7H3 Human Inquiry
BSFV-H238 Recombinant Human Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human B7H3 Human Inquiry
SCTB-036 Recombinant Anti-B7H3 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse B7H3 Mouse Inquiry
SCDB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse B7H3 Mouse Inquiry
FABIG-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse B7H3 Mouse Inquiry
TRIB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse B7H3 Mouse Inquiry
BSIG-064 Anti-CD3 x Anti-B7H3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse B7H3 Mouse Inquiry
CROSSAB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse B7H3 Mouse Inquiry
IGFV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse B7H3 Mouse Inquiry
BSDB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse B7H3 Mouse Inquiry
BSFAB-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse B7H3 Mouse Inquiry
BSFV-064 Recombinant Anti-CD3 x Anti-B7H3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse B7H3 Mouse Inquiry

Background

B7-H3, also known as CD276 or B7RP-2, is a member of the B7 ligand family and is a 316 amino acid long type I transmembrane protein encoded by a gene on mouse chromosome 9 and human 15q24. B7-H3 is an immune checkpoint molecule that belongs to the B7-CD28 pathway and has both immune and non-immune functions. B7-H3 has been shown to have other non-immune effects and may affect chemotherapy sensitivity and cancer metastasis by interfering with different signaling pathways. B7-H3 appears to be the "right" tumor antigen for antibody-based immunotherapy, and its appeal as a target for tumor antibody therapy has inspired the development of immunotherapy strategies targeting B7-H3. B7-H3 may inhibit natural killer (NK) cell activation and promote cytokine release from monocytes and/or macrophages in a Toll-like receptor (TLR)-2 and TLR-4 dependent manner.

Fig.1 Schematic representation of possible functions of B7-H3-mediated tumor cell immunity. (Wang, 2014) Fig.1 Schematic representation of possible functions of B7-H3-mediated tumor cell immunity.1

Reference

  1. Wang, Ling, Fu‐Biao Kang, and Bao‐En Shan. "B7‐H3‐mediated tumor immunology: friend or foe?." International journal of cancer 134.12 (2014): 2764-2771.
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