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CSF1 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H310 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CSF1 Human IL34 Human Inquiry
T-BSDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CSF1 Mouse IL34 Mouse Inquiry
SCIGG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scIgG) Human Single chain IgGs CSF1 Human IL34 Human Inquiry
SCIGG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scIgG) Human Single chain IgGs CSF1 Mouse IL34 Mouse Inquiry
FVTIG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CSF1 Human IL34 Human Inquiry
FVTIG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CSF1 Mouse IL34 Mouse Inquiry
BSSG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-IgG) Human scFv-IgG CSF1 Human IL34 Human Inquiry
BSSG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-IgG) Human scFv-IgG CSF1 Mouse IL34 Mouse Inquiry
IGLFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CSF1 Human IL34 Human Inquiry
IGLFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CSF1 Mouse IL34 Mouse Inquiry
BSGV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (IgG-Fv) Human IgG-Fv CSF1 Mouse IL34 Mouse Inquiry
BSGV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-Fv) Human IgG-Fv CSF1 Mouse IL34 Mouse Inquiry
BSDG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fv-IgG) Human Fv-IgG CSF1 Human IL34 Human Inquiry
BSDG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fv-IgG) Human Fv-IgG CSF1 Mouse IL34 Mouse Inquiry
BABFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CSF1 Human IL34 Human Inquiry
BABFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CSF1 Mouse IL34 Mouse Inquiry
FABVC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CSF1 Human IL34 Human Inquiry
FABVC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CSF1 Mouse IL34 Mouse Inquiry
SCDBC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CSF1 Human IL34 Human Inquiry
SCDBC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CSF1 Mouse IL34 Mouse Inquiry
BSDBC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CSF1 Human IL34 Human Inquiry
BSDBC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CSF1 Mouse IL34 Mouse Inquiry
SCDBF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CSF1 Human IL34 Human Inquiry
SCDBF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CSF1 Mouse IL34 Mouse Inquiry
BSFVF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CSF1 Human IL34 Human Inquiry
BSFVF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CSF1 Mouse IL34 Mouse Inquiry
BSDBF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CSF1 Human IL34 Human Inquiry
BSDBF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CSF1 Mouse IL34 Mouse Inquiry
BSTF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CSF1 Mouse IL34 Mouse Inquiry
BSTF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CSF1 Mouse IL34 Mouse Inquiry
BSCFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-Fc) Human scFv-Fc CSF1 Mouse IL34 Mouse Inquiry
BSCFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-Fc) Human scFv-Fc CSF1 Mouse IL34 Mouse Inquiry
MNAB-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Miniantibody) Human Miniantibody CSF1 Mouse IL34 Mouse Inquiry
MNAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Miniantibody) Human Miniantibody CSF1 Mouse IL34 Mouse Inquiry
BSFC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CSF1 Mouse IL34 Mouse Inquiry
BSFC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CSF1 Mouse IL34 Mouse Inquiry
BSCC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CSF1 Mouse IL34 Mouse Inquiry
BSCC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CSF1 Mouse IL34 Mouse Inquiry
BIBD-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Bibody) Human Bibody CSF1 Mouse IL34 Mouse Inquiry
BIBD-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Bibody) Human Bibody CSF1 Mouse IL34 Mouse Inquiry
FABFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fab-Fv) Human Fab-Fv CSF1 Human IL34 Human Inquiry
FABFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-Fv) Human Fab-Fv CSF1 Mouse IL34 Mouse Inquiry
MiniB-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Minibody) Human Minibody CSF1 Human IL34 Human Inquiry
MiniB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Minibody) Human Minibody CSF1 Mouse IL34 Mouse Inquiry
SCDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CSF1 Human IL34 Human Inquiry
FABIG-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-IgG) Human Fab-IgG CSF1 Human IL34 Human Inquiry
TRIB-H312 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CSF1 Human IL34 Human Inquiry
BSIG-H310 Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-IgG) Human IgG-IgG CSF1 Human IL34 Human Inquiry
CROSSAB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (CrossMab) Human CrossMab CSF1 Human IL34 Human Inquiry
IGFV-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-scFv) Human IgG-scFv CSF1 Human IL34 Human Inquiry
BSDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody) Human Diabody CSF1 Human IL34 Human Inquiry
BSFAB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Fab) Human Tandem Fab CSF1 Human IL34 Human Inquiry
BSFV-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv) Human Tandem scFv CSF1 Human IL34 Human Inquiry
SCDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CSF1 Mouse IL34 Mouse Inquiry
FABIG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-IgG) Human Fab-IgG CSF1 Mouse IL34 Mouse Inquiry
TRIB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CSF1 Mouse IL34 Mouse Inquiry
BSIG-143 Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-IgG) Human IgG-IgG CSF1 Mouse IL34 Mouse Inquiry
CROSSAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (CrossMab) Human CrossMab CSF1 Mouse IL34 Mouse Inquiry
IGFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-scFv) Human IgG-scFv CSF1 Mouse IL34 Mouse Inquiry
BSDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody) Human Diabody CSF1 Mouse IL34 Mouse Inquiry
BSFAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Fab) Human Tandem Fab CSF1 Mouse IL34 Mouse Inquiry
BSFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv) Human Tandem scFv CSF1 Mouse IL34 Mouse Inquiry

Background

The Colony Stimulating Factor 1 (CSF1), whose alternative name is Macrophage Colony-Stimulating Factor (M-CSF), stands as a critical hematopoietic growth factor essential for the proliferation, survival, and differential of macrophages, monocytes, and bone marrow progenitor cells. Recent research highlights the therapeutic potential of CSF1 in inhibiting the recruitment of tissue-adapted macrophages for tumor treatment. Eukaryotic cells also generate M-CSF as a defense against intercellular viral infections. Interacting with its membrane receptor, M-CSF modulates the proliferation of early hematopoietic progenitors, influencing diverse physiological processes related to immunology, metabolism, fertility, and pregnancy. The active protein form of CSF1 is extracellularly located as a disulfide-linked homodimer, believed to originate from the proteolytic cleavage of membrane-bound precursors.

Tumor-Associated Macrophages (TAM) orchestrating tumor invasion and metastasis through CSF-1 regulation. (Dwyer, et al., 2017) Fig.1 Tumor-Associated Macrophages (TAM) orchestrating tumor invasion and metastasis through CSF-1 regulation.1

Reference

  1. Dwyer, Amy R., Eloise L. Greenland, and Fiona J. Pixley. "Promotion of tumor invasion by tumor-associated macrophages: the role of CSF-1-activated phosphatidylinositol 3 kinase and Src family kinase motility signaling." Cancers 9.6 (2017): 68.
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