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IGF1R Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSFAB-PAP011 Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFAB-SAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-SAP029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFAB-SAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-SAP011 Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFAB-RTA034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-RTA029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFAB-RTA016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-RTA011 Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFAB-GEL034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-GEL029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFAB-GEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-GEL011 Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFAB-PE034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-PE029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFAB-PE016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-PE011 Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFAB-DT034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-DT029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFAB-DT016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-DT011 Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFV-SAR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-SAR029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFV-SAR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-SAR011 Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFV-NGB034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-NGB029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFV-NGB016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-NGB011 Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFV-MEL034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-MEL029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFV-MEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-MEL011 Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFV-BGN034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-BGN029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFV-BGN016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-BGN011 Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFV-ABR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-ABR029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFV-ABR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-ABR011 Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
BSFV-PAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-PAP029 Recombinant Human Anti-EGFR x Human Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human IGF1R Human Inquiry
BSFV-PAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-PAP011 Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse IGF1R Mouse Inquiry
SCTB-H162 Recombinant Human Anti-IGF1R x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human IGF1R Human Inquiry
SCDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Human IGF1R Human Inquiry
SCDB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Human IGF1R Human Inquiry
SCDB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human IGF1R Human Inquiry
FABIG-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Human IGF1R Human Inquiry
FABIG-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Human IGF1R Human Inquiry
FABIG-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human IGF1R Human Inquiry
TRIB-H335 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Human IGF1R Human Inquiry
TRIB-H325 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Human IGF1R Human Inquiry
TRIB-H268 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human IGF1R Human Inquiry
BSIG-H333 Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Human IGF1R Human Inquiry
BSIG-H323 Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Human IGF1R Human Inquiry
BSIG-H266 Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human IGF1R Human Inquiry
CROSSAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab HER3 Human IGF1R Human Inquiry
CROSSAB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab EGFR Human IGF1R Human Inquiry
CROSSAB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab CD3 Human IGF1R Human Inquiry
IGFV-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Human IGF1R Human Inquiry
IGFV-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Human IGF1R Human Inquiry
IGFV-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human IGF1R Human Inquiry
BSDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Human IGF1R Human Inquiry
BSDB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody EGFR Human IGF1R Human Inquiry
BSDB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody CD3 Human IGF1R Human Inquiry
BSFAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Human IGF1R Human Inquiry
BSFAB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Human IGF1R Human Inquiry
BSFAB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human IGF1R Human Inquiry
BSFV-H331 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Human IGF1R Human Inquiry
BSFV-H321 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Human IGF1R Human Inquiry
BSFV-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human IGF1R Human Inquiry
SCTB-065 Recombinant Anti-IGF1R x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse IGF1R Mouse Inquiry
SCDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Mouse IGF1R Mouse Inquiry
SCDB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Mouse IGF1R Mouse Inquiry
SCDB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse IGF1R Mouse Inquiry
FABIG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Mouse IGF1R Mouse Inquiry
FABIG-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse IGF1R Mouse Inquiry
FABIG-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse IGF1R Mouse Inquiry
TRIB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Mouse IGF1R Mouse Inquiry
TRIB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse IGF1R Mouse Inquiry
TRIB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse IGF1R Mouse Inquiry
BSIG-169 Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Mouse IGF1R Mouse Inquiry
BSIG-157 Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse IGF1R Mouse Inquiry
BSIG-092 Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse IGF1R Mouse Inquiry
CROSSAB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse IGF1R Mouse Inquiry
CROSSAB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse IGF1R Mouse Inquiry
IGFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Mouse IGF1R Mouse Inquiry
IGFV-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse IGF1R Mouse Inquiry
IGFV-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse IGF1R Mouse Inquiry
BSDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Mouse IGF1R Mouse Inquiry
BSDB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody EGFR Mouse IGF1R Mouse Inquiry
BSDB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody CD3 Mouse IGF1R Mouse Inquiry
BSFAB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Mouse IGF1R Mouse Inquiry
BSFAB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse IGF1R Mouse Inquiry
BSFAB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse IGF1R Mouse Inquiry
BSFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Mouse IGF1R Mouse Inquiry
BSFV-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse IGF1R Mouse Inquiry
BSFV-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse IGF1R Mouse Inquiry

Background

IGF1R is classified as a receptor tyrosine kinase involved in the regulation of cellular growth and proliferation, acting through mechanisms initiated by its ligands, IGF1, IGF2, and insulin.

Upon binding with these ligands, IGF1R undergoes phosphorylation and facilitates signal transduction through insulin receptor substrates and Src homology collagen proteins, which subsequently activate the downstream signals of MAPK and PI3K/AKT. Activation of IGF1R is instrumental in governing various cellular processes, including differentiation, proliferation, and apoptosis.

Moreover, IGF1R stimulation is believed to exert influence on cellular autophagy and induce an enhanced autophagic response under hypoxic conditions. Indicative of its heightened versatility, recent studies have provided evidence of ligand-independent and kinase-independent signaling of IGF1R through GPCR system components. Furthermore, IGF1R is implicated in the pathology of various forms of cancer and plays a complex role in host responses to viral infections.

IGF1 and IGF1R pathway. (Crudden, et al., 2015)Fig.1 IGF1 and IGF1R pathway.1

Reference

  1. Crudden, Girnita, et al. " Targeting the IGF-1R: the tale of the tortoise and the hare." Frontiers in Endocrinology. 6 (2015): 64.
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