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IL34 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H310 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CSF1 Human IL34 Human Inquiry
T-BSDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CSF1 Mouse IL34 Mouse Inquiry
SCIGG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scIgG) Human Single chain IgGs CSF1 Human IL34 Human Inquiry
SCIGG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scIgG) Human Single chain IgGs CSF1 Mouse IL34 Mouse Inquiry
FVTIG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CSF1 Human IL34 Human Inquiry
FVTIG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CSF1 Mouse IL34 Mouse Inquiry
BSSG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-IgG) Human scFv-IgG CSF1 Human IL34 Human Inquiry
BSSG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-IgG) Human scFv-IgG CSF1 Mouse IL34 Mouse Inquiry
IGLFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CSF1 Human IL34 Human Inquiry
IGLFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CSF1 Mouse IL34 Mouse Inquiry
BSGV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (IgG-Fv) Human IgG-Fv CSF1 Mouse IL34 Mouse Inquiry
BSGV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-Fv) Human IgG-Fv CSF1 Mouse IL34 Mouse Inquiry
BSDG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fv-IgG) Human Fv-IgG CSF1 Human IL34 Human Inquiry
BSDG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fv-IgG) Human Fv-IgG CSF1 Mouse IL34 Mouse Inquiry
BABFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CSF1 Human IL34 Human Inquiry
BABFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CSF1 Mouse IL34 Mouse Inquiry
FABVC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CSF1 Human IL34 Human Inquiry
FABVC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CSF1 Mouse IL34 Mouse Inquiry
SCDBC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CSF1 Human IL34 Human Inquiry
SCDBC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CSF1 Mouse IL34 Mouse Inquiry
BSDBC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CSF1 Human IL34 Human Inquiry
BSDBC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CSF1 Mouse IL34 Mouse Inquiry
SCDBF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CSF1 Human IL34 Human Inquiry
SCDBF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CSF1 Mouse IL34 Mouse Inquiry
BSFVF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CSF1 Human IL34 Human Inquiry
BSFVF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CSF1 Mouse IL34 Mouse Inquiry
BSDBF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CSF1 Human IL34 Human Inquiry
BSDBF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CSF1 Mouse IL34 Mouse Inquiry
BSTF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CSF1 Mouse IL34 Mouse Inquiry
BSTF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CSF1 Mouse IL34 Mouse Inquiry
BSCFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-Fc) Human scFv-Fc CSF1 Mouse IL34 Mouse Inquiry
BSCFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-Fc) Human scFv-Fc CSF1 Mouse IL34 Mouse Inquiry
MNAB-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Miniantibody) Human Miniantibody CSF1 Mouse IL34 Mouse Inquiry
MNAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Miniantibody) Human Miniantibody CSF1 Mouse IL34 Mouse Inquiry
BSFC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CSF1 Mouse IL34 Mouse Inquiry
BSFC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CSF1 Mouse IL34 Mouse Inquiry
BSCC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CSF1 Mouse IL34 Mouse Inquiry
BSCC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CSF1 Mouse IL34 Mouse Inquiry
BIBD-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Bibody) Human Bibody CSF1 Mouse IL34 Mouse Inquiry
BIBD-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Bibody) Human Bibody CSF1 Mouse IL34 Mouse Inquiry
FABFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fab-Fv) Human Fab-Fv CSF1 Human IL34 Human Inquiry
FABFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-Fv) Human Fab-Fv CSF1 Mouse IL34 Mouse Inquiry
MiniB-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Minibody) Human Minibody CSF1 Human IL34 Human Inquiry
MiniB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Minibody) Human Minibody CSF1 Mouse IL34 Mouse Inquiry
SCDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CSF1 Human IL34 Human Inquiry
FABIG-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-IgG) Human Fab-IgG CSF1 Human IL34 Human Inquiry
TRIB-H312 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CSF1 Human IL34 Human Inquiry
BSIG-H310 Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-IgG) Human IgG-IgG CSF1 Human IL34 Human Inquiry
CROSSAB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (CrossMab) Human CrossMab CSF1 Human IL34 Human Inquiry
IGFV-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-scFv) Human IgG-scFv CSF1 Human IL34 Human Inquiry
BSDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody) Human Diabody CSF1 Human IL34 Human Inquiry
BSFAB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Fab) Human Tandem Fab CSF1 Human IL34 Human Inquiry
BSFV-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv) Human Tandem scFv CSF1 Human IL34 Human Inquiry
SCDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CSF1 Mouse IL34 Mouse Inquiry
FABIG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-IgG) Human Fab-IgG CSF1 Mouse IL34 Mouse Inquiry
TRIB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CSF1 Mouse IL34 Mouse Inquiry
BSIG-143 Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-IgG) Human IgG-IgG CSF1 Mouse IL34 Mouse Inquiry
CROSSAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (CrossMab) Human CrossMab CSF1 Mouse IL34 Mouse Inquiry
IGFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-scFv) Human IgG-scFv CSF1 Mouse IL34 Mouse Inquiry
BSDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody) Human Diabody CSF1 Mouse IL34 Mouse Inquiry
BSFAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Fab) Human Tandem Fab CSF1 Mouse IL34 Mouse Inquiry
BSFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv) Human Tandem scFv CSF1 Mouse IL34 Mouse Inquiry

Background

IL-34 signaling pathways are crucial in macrophage differentiation. (Muñoz-Garcia, et al., 2021)Fig.1 IL-34 signaling pathways are
crucial in macrophage differentiation.1

Interleukin-34 (IL-34) is a cytokine that is essential for tissue homeostasis and immune system control. It stimulates and differentiates monocytes and macrophages by binding to its receptor on the surface of progenitor cells, colony-stimulating factor 1 receptor (CSF1R). This promotes their maturation into functional macrophages and regulates their survival and activation. IL-34 has been implicated in various pathological conditions, including autoimmune diseases, bone metabolism, cancer, and neurodegenerative disorders. In cancer, IL-34 can promote tumor growth by enhancing immune evasion and creating an immunosuppressive environment. The possibility of targeting IL-34 signaling pathways as a treatment strategy for these diseases is being studied. Overall, IL-34 is a key cytokine involved in monocyte/macrophage biology and exhibits potential as a therapeutic target in various disease settings.

Reference

  1. Muñoz-Garcia, Javier, et al. "The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis." Theranostics 11.4 (2021): 1568.
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