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Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin)  (BSFV-SAR031)

Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the α-Sarcin (SAR) fused to a tandem scFv recognizing HER1 and HER3. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver SAR to antigen-specific cells. Then SAR is a ribonuclease which can inhibit protein synthesis and kill the target cells. The bispecific immunotoxin is designed for the research of Head and neck cancer; Colorectal cancer therapy.

Specifications

Targets
HER1 & HER3
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
HER1
Host Animal 1
Human
Target 2
HER3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Head and neck cancer; Colorectal cancer

Targets

Target 1
HER1
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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