Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCadherins (CDHs) are a class of calcium-dependent transmembrane proteins featured by the presence of at least 2 consecutive extracellular cadherin-specific motifs (cadherin repeats) with several conserved calcium-binding amino acid residues. They belong to a superfamily of adhesion molecules and mediate calcium-dependent homophilic cell-cell adhesion or cell-cell recognition, and signal transductions by interacting with cytoplasmic proteins. Cadherins are also responsible for the tissue morphogenesis and tumor suppression. As the Ca2+-dependent adhesion molecule, the classic cadherins in this group are the best studied. They include epithelial cadherin (E-cadherin, CDH1), neural cadherin (N-cadherin, CDH12), placental cadherin (P-cadherin, CDH3) together with retinal cadherin (R-cadherin). The classic cadherins are originally named after the tissue where they were first found, however, their distributions are definitely not limited to these tissues. Brain tissue expresses at least 20 types, and possibly more, the individual cadherin which functions the cell-cell interaction, differential neurite outgrowth, and locking in pre- and postsynaptic membranes at the synaptic junctional complex.
There are more than 100 different types of cadherins detected in vertebrates, which can be divided into four groups: classical, protocadherins, desmosomal, and unconventional types. This large number of diversity is performed by multiple cadherin encoding genes combined with alternative RNA splicing mechanisms. Here shows part of cadherin members in humans.
With the assist of cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is a pleasure to provide the preparation of these membrane proteins in required formats by using numerous strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Together, our MemDX™ membrane protein antibody discovery system is able to help find antibodies against these target proteins, even fully humanized antibodies, through varieties of approaches including phage display technology, hybridoma technology, and so like. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
