Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCopper-transporting ATPase (Cu-ATPase) is a copper transporting protein that transport copper ions into and out of cells to balance the copper level in the body using the energy from ATP hydrolysis. Copper plays a very important role in cell metabolism. And it acts as a cofactor of key enzymes involved in respiration, photosynthesis, detoxification of free radicals, iron uptake, neurotransmitter biosynthesis and so on. Structure analysis of Cu-ATPases suggests it has a characteristic catalytic domain which contains an evolutionarily conserved aspartate residue phosphorylated by ATP to form a phosphoenzyme intermediate. The pass-membrane region of Cu-ATPases contains a cation-binding cysteine-proline-cysteine/histidine/serine (CPx) motif responsible for catalytic activation and cation translocation. Besides, the N-terminal of Cu-ATPases contains the binding sites of copper ions.
Here shows part of Cu-ATPase in humans including ATP7A and ATP7B, encoded by ATP7A and ATP7B, respectively. The two subtypes of Cu-ATPase are present in the trans-Golgi network. They are both the essential copper pumps that maintain the intracellular copper homeostasis. And their functions are associated with the distinct intracellular targeting of the transporters.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
