Biomarker and Antibody Development for Osteoarthritis

Creative Biolabs is a well-recognized expert in the field of antibody generation and production. Especially, we have launched a series of in vitro diagnostic (IVD) antibody development services for different infections and diseases. Here, we introduce our antibody development services targeting different biomarkers of osteoarthritis.


Osteoarthritis (OA) is the most common form of arthritis affecting about 3.3% of the population. It is a type of joint disease that results from breakdown of joint cartilage and underlying bone. Among those over 60 years old, about 10% of males and 18% of females are affected. It is the cause of about 2% of years lived with disability. It becomes more common in both sexes as people become older. Treatment includes exercise, efforts to decrease joint stress, support groups, and pain medications. Efforts to decrease joint stress include resting and the use of a cane. Weight loss may help in those who are overweight. Pain medications may include paracetamol (acetaminophen) as well as NSAIDs such as naproxen or ibuprofen. Long-term opioid use is generally discouraged due to lack of information on benefits as well as risks of addiction and other side effects. If pain interferes with normal life despite other treatments, joint replacement surgery may help.

Osteoarthritis – Creative Biolabs


Common signs and symptoms of osteoarthritis often develop slowly and worsen over time, including:

  • Pain: causing loss of ability and often stiffness.
  • Stiffness: most common in the morning, and typically lasts less than half an hour after beginning daily activities, but may return after periods of inactivity.
  • Loss of flexibility: joint swelling, decreased range of motion, and when the back is affected weakness or numbness of the arms and legs.
  • Tenderness: your joint may feel tender when you apply light pressure to it.
  • Grating sensation: osteoarthritis can cause a crackling noise when the affected joint is moved.
  • Bone spurs: may form around the affected joint.
Osteoarthritis – Creative Biolabs

Risk Factor

Damage from mechanical stress with insufficient self-repair by joints is believed to be the primary cause of osteoarthritis. Other risk factors may include:

  • Congenital or pathogenic causes
  • Mechanical injury
  • Excess body weight
  • Changes in sex hormone levels
  • Inherited factors


Osteoarthritis is a slow-developing disease which is hard to diagnose until it starts to cause painful or debilitating symptoms. Early osteoarthritis is often diagnosed after an accident or other incident that causes a fracture requiring an X-ray. In addition to X-rays, doctors may also use an MRI scan. This imaging test uses radio waves and a magnetic field to create images of bone and soft tissue. Other diagnostic tests include a blood test to either support or rule out other problems that cause joint pain. A joint fluid analysis can also be used to determine whether gout or infection is the underlying cause of inflammation.

Novel IVD antibodies are required to be developed for the development of diagnostic immunoassays. Scientific progress has resulted in the discovery of novel disease biomarkers to fulfill the need for a quicker, more specific and more accurate diagnosis of osteoarthritis. If you are interested in our IVD antibody discovery services, please contact us for more details.

At Creative Biolabs, we offer high-quality IVD antibody development services against different diagnostic biomarkers of osteoarthritis, including but not limited to:

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